Abstract: Simultaneous biological carbon，nitrogen and sulfur removal is drawing increasing interest by exploring an economical and efficient wastewater treatment system． However，simultaneous denitrifying sulfide removal and sulfatedependent ANAMMOX have not been investigated until recently． Most research on denitrifying sulfide removal is limited to bioreactor performance，loading and operating conditions． It is necessary to establish the underlying principles of the biochemical reactions and the mechanisms of the microbial degradation． Thus，this paper summarized the bioreactor operation， performance，modeling set-up and corresponding microbial community． Finally，future work on simultaneous biological nitrogen，sulfur，carbon removal is put forward．