Abstract: High temperature aerobic biological drying technology is effective in solving the problem of high water content, high organic matter existing in domestic waste drying in China, while the micro mechanism and influencing factors of high temperature aerobic biological drying process were very complex. On the basis of the experiments of high temperature aerobic biological drying of garbage, the important factors on biological drying were:organic matter content, microbial species, ventilation air volume, bin structure, oxygen concentration, particle size and bin insulation; the suitable range of main influence factors of high temperature aerobic biological drying was preliminarily determined as follows: the content of organic matter in garbage should be more than 15%, and suitable high temperature aerobic microbial bacteria should be inoculated (living bacteria dosage of 10⁶~10¹⁰ CFU/mL, and the inoculation amount was about 1.5 L/t), the particle size of garbage was controlled at 95% ＜160 mm, and the ventilation air volume should meet the demand of O₂ and dehumidification in the process of organic matter decomposition. The results could prouide data reference for researches on the process mechanism of high temperature aerobic biological drying technology of domestic waste.