Abstract: In order to reduce dust pollution and protect the health of indoor operators in power plants, the pulverized coal particle release model, settling model and gas-particle two-phase flow physical model were established. And multi-phase flow numerical simulation method was used to simulate the dust flow and distribution before and after the treatment of the plant, based on the mechanism of dust floating and flying. The results showed that the dust concentration could be effectively reduced by adjusting the ventilation position of the workshop. Indoor workers could effectively reduce the degree of contamination by using appropriate operation methods and locating in the right direction. It was concluded that the prediction of dust movement law could provide theoretical guidance and basis for dust control in the related industries.