甾体类药物发酵菌渣的无害化与资源化研究进展

郭李恒; 关小红; 刘惠玲; 戴晓虎

doi:10.13205/j.hjgc.202205034

甾体类药物发酵菌渣的无害化与资源化研究进展

doi: 10.13205/j.hjgc.202205034

同济大学环境科学与工程学院, 上海 200092

基金项目:

国家重点研发计划“高含固有机固废高效制备生物燃气的多介质强化传热传质与物质转化机理研究”(2018YFC1900902)

详细信息

作者简介:
郭李恒(1996-),男,硕士,主要研究方向为甾体类药物菌渣无害化与资源化。1930498@tongji.edu.cn

通讯作者:
刘惠玲(1964-),女,博士,教授,主要研究方向为固体废弃物的无害化处理与资源化利用。liuhuiling@tongji.edu.cn

计量
- 文章访问数: 247
- HTML全文浏览量: 36
- PDF下载量: 13
- 被引次数: 0
出版历程
- 收稿日期: 2021-04-27
- 网络出版日期: 2022-07-02

RESEARCH PROGRESS ON HARMLESS AND RESOURCE UTILIZATION OF FERMENTATION RESIDUE OF STEROIDAL DRUGS

College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China

摘要

摘要: 我国为甾体类原料药的生产大国,微生物转化法生产甾体药物的过程中产生的发酵菌渣是一种非常宝贵的资源,但发酵菌渣中仍存在少量有毒的甾体类残留物,在我国被列入《国家危险废物名录》。目前,甾体药物发酵菌渣的处理仍存在一定困难,严重制约着制药企业的健康发展,为此很多研究者针对药物发酵菌渣的无害化与资源化途径开展了广泛的研究。从甾体类药物发酵菌渣的来源、污染属性及国家相关管理要求等方面入手,分别综述了目前包括水热处理、碱热处理、微波处理等预处理技术,燃料化、肥料化、材料化等资源化利用技术,焚烧处置、安全填埋等处置技术在内的甾体药物发酵菌渣无害化与资源化方面的研究现状与最新进展,并对不同处理处置技术的可行性与可操作性进行了综合分析,最后对该领域未来的研究方向进行展望。
- 甾体 /
- 菌渣 /
- 无害化 /
- 资源化
Abstract: China is a major producer of steroidal APIs. The fermentation residue produced during the production of steroidal drugs by microbial transformation is a very valuable resource. However, there are still a small amount of toxic steroid residues in the fermentation residue, which is listed as national hazardous waste by the Ministry of Environmental Protection in China. At present, there are still some difficulties in the treatment of steroid drug fermentation residue, which has severely restricted the healthy development of pharmaceutical enterprises. For this reason, many researchers have conducted extensive research on the harmlessness and resource utilization of the residue. This paper starts with the source, pollution property and management requirements of steroid drug fermentation residue, and reviews its current research status and latest progress in the harmless and resource utilization, including pretreatment technologies such as hydrothermal treatment, alkali heat treatment and microwave treatment, resource utilization technologies such as fuel, fertilization and materialization, incineration, etc. The feasibility and operability of different treatment and disposal technologies were comprehensively analyzed, and finally the future research directions in this field were prospected.
- steroids /
- bacterial residue /
- harmless /
- resource utilization

HTML全文

参考文献(60)

[1]	季晖.药理学[M].南京:东南大学出版社,2019.
[2]	FERNANDES P,CRUZ A,ANGELOVA B,et al.Microbial conversion of steroid compounds:recent developments[J].Enzyme and Microbial Technology,2003,32(6):688-705.
[3]	徐松.中国医药产业技术创新研究[D].武汉:武汉大学,2017.
[4]	龚金梅,肖红卫,安庆,等.甾体类激素原料药地塞米松生产工艺与市场分析[J].云南科技管理,2012,25(6):69-72.
[5]	EHRENSTEIN M,STEVENS T O.Investigations on steroids.Ⅳ.New degradation products of cholic acid and studies on the synthesis of 7,12-dihydroxyprogesterone1[J].The Journal of Organic Chemistry,1940,5(6):660-673.
[6]	MARKER R E,TURNER D L,ULSHAFER P R.Sterols.CIV.diosgenin from certain american plants[J].Journal of the American Chemical Society,1940,62(9):2542-2543.
[7]	KOCH F C.A spayed-rat estrogen assay method and its application to pure estrogens and urine extract1[J].Endocrinology,1942,31(2):162-166.
[8]	马如鸿,刘其明.我国甾体药物三十年成就[J].中国药物化学杂志,1991(1):49-67.
[9]	黄鸣龙.甾体激素化学在我国近十年来的进展[J].药学学报,1960(1):1-14.
[10]	黄燕霞.薯蓣皂素生产工艺的研究进展[J].上海中医药杂志,2004(4):56-58.
[11]	彭莺,刘福祯,高欣.天然植物甾醇的应用与提取工艺[J].化工进展,2002(1):49-53.
[12]	药智网.甾体药物行业市场现状与发展趋势分析[EB/OL].[03-15].https://news.yaozh.com/archive/21638.html.
[13]	王鸿,周启春,邵燕燕,等.雄烯二酮的微生物生产与转化研究进展[J].浙江工业大学学报,2015,43(6):611-617.
[14]	张峥斌.生物法制备雄烯二酮[Z].2017.
[15]	刘喜荣.植物甾醇法生产醋酸氢化可的松新工艺[Z].2014.
[16]	SHAO M L,ZHANG X,RAO Z M,et al.Enhanced production of androst-1,4-diene-3,17-dione by Mycobacterium neoaurum JC-12 using three-stage fermentation strategy[J].PLoS One,2015,10(9):e137658.
[17]	高兴强.基于代谢组学分析的分枝杆菌转化植物甾醇产甾体药物中间体的研究[D].上海:华东理工大学,2015.
[18]	朱培,张建斌,陈代杰.抗生素菌渣处理的研究现状和建议[J].中国抗生素杂志,2013,38(9):647-651.
[19]	汤少红,石伟勇,董越勇.生物制药药渣资源化利用途径的研究[J].农业环境科学学报,2006(增刊1):234-236.
[20]	王惠武.开发利用抗生素菌渣作为饲料营养添加剂的调查[J].饲料研究,1988,10(12):25-26.
[21]	TOKARZ J,MÖLLER G,HRABĔ DE ANGELIS M,et al.Zebrafish and steroids:What do we know and what do we need to know?[J].The Journal of Steroid Biochemistry and Molecular Biology,2013,137(1):165-173.
[22]	中华人民共和国生态环境部.国家危险废物名录(2021年版)[EB/OL].
[23]	ZHANG G Y,LI C X,MA D C,et al.Anaerobic digestion of antibiotic residue in combination with hydrothermal pretreatment for biogas[J].Bioresource Technology,2015,192(1):257-265.
[24]	CAI C,HUA Y,LI H P,et al.Hydrothermal treatment of erythromycin fermentation residue:harmless performance and bioresource properties[J].Resources,Conservation and Recycling,2020,161(1):104952.
[25]	王志强.青霉素菌渣水热液化制备生物油及机理研究[D].北京:北京科技大学,2019.
[26]	李春星.水热预处理提高抗生素菌渣厌氧消化甲烷化[D].湘潭:湘潭大学,2015.
[27]	赵燕肖,习彦华,饶硕,等.碱热预处理对青霉素菌渣厌氧发酵产沼气效率的影响[J].中国沼气,2017,35(5):3-8.
[28]	ZHONG W Z,LI Z X,YANG J L,et al.Effect of thermal-alkaline pretreatment on the anaerobic digestion of streptomycin bacterial residues for methane production[J].Bioresource Technology,2014,151(3):436-440.
[29]	苑丽梅.头孢菌渣中残留效价检测方法及菌渣资源化可行性研究[D].哈尔滨:哈尔滨工业大学,2014.
[30]	CAI C,LIU H L,WANG B.Performance of microwave treatment for disintegration of cephalosporin mycelial dreg (CMD) and degradation of residual cephalosporin antibiotics[J].Journal of Hazardous Materrials,2017,331(3):265-272.
[31]	ZHANG Y X,LIU H L,XIN Y J,et al.Erythromycin degradation and ERY-resistant gene inactivation in erythromycin mycelial dreg by heat-activated persulfate oxidation[J].Chemical Engineering Journal,2019,358(5):1446-1453.
[32]	钟为章,耿晓玲,李贵霞,等.微波-碱预处理对土霉素菌渣减量化效果研究[J].河北科技大学学报,2016,37(4):390-395.
[33]	钟为章,李玉冰,高湘,等.碱/超声预处理对头孢菌素菌渣破壁效果的影响[J].环境工程,2016,34(5):99-103.
[34]	李士兰,何辰庆.以卡娜霉素制药废渣和酒槽为原料制取沼气发酵条件的研究[J].微生物学杂志,1988(2):11-15.
[35]	闫阳.庆大霉素菌渣厌氧发酵试验研究[D].郑州:郑州大学,2014.
[36]	董永博.青霉素菌渣厌氧发酵制取沼气工艺研究[D].哈尔滨:哈尔滨工业大学,2014.
[37]	纪钧麟,杨智明,尹芳,等.甾体制药渣发酵产沼气实验研究[J].中国沼气,2019,37(5):27-33.
[38]	LI C X,ZHANG G Y,ZHANG Z K,et al.Alkaline thermal pretreatment at mild temperatures for biogas production from anaerobic digestion of antibiotic mycelial residue[J].Bioresource Technology,2016,208(5):49-57.
[39]	SONG S Q,JIANG M Y,YAO J,et al.Anaerobic digestion of spectinomycin mycelial residues pretreated by thermal hydrolysis:removal of spectinomycin and enhancement of biogas production[J].Environmental Science and Pollution Research,2020,27(31):39297-39307.
[40]	张倩倩.抗生素菌渣的堆肥处理研究[D].郑州:郑州大学,2019.
[41]	WANG B,LI G M,CAI C,et al.Assessing the safety of thermally processed penicillin mycelial dreg following the soil application:Organic matter's maturation and antibiotic resistance genes[J].Science of the Total Environment,2018,636(7):1463-1469.
[42]	郭夏丽,席晓黎,张红娟,等.抗生素菌渣堆肥进程中微生物群落的变化[J].环境工程学报,2012,6(12):4671-4675.
[43]	张红娟.抗生素菌渣堆肥化处理研究[D].郑州:郑州大学,2010.
[44]	张诗华.青霉素菌渣混合市政污泥好氧堆肥工艺效能研究[D].哈尔滨:哈尔滨工业大学,2016.
[45]	平然,任爱玲,田书磊,等.两种抗生素菌渣经SEA-CBS技术处理后的肥料特性[J].环境科学研究,2019,32(11):1945-1951.
[46]	郭夏丽,张静晓,王静,等.菌渣和牛粪联合堆肥中的氮素转化研究[J].郑州大学学报(工学版),2012,33(1):71-74.
[47]	张晔,李寒旭,芦涛,等.淮北矿区煤与抗生素湿菌渣配合制备水煤浆的试验研究[J].选煤技术,2010(1):24-27.
[48]	周保华,高勤,郭斌,等.响应面法优化青霉素菌渣活性炭制备技术的研究[J].河北科技大学学报,2012,33(6):554-558.
[49]	吴萍,李正鹏,饶圣宏,等.利用废菌渣生产单细胞蛋白饲料研究[J].中国饲料,2008(22):38-41.
[50]	程俊山,张京伟,徐绍辉,等.青霉素菌渣中提取麦角固醇工艺的研究[J].河北化工,2009,32(9):22-24.
[51]	马玉龙,刘宁普,张作义,等.利用泰乐菌素菌渣生产复合酶制剂及效果研究[J].环境科学与技术,2011,34(10):134-137.
[52]	王冰.青霉素菌渣制取饲料酵母与酵母膏的工艺研究[D].哈尔滨:哈尔滨工业大学,2013.
[53]	李金惠,余嘉栋,缪友萍.我国固体废物处理处置演变情况分析[J].环境保护,2019,47(17):32-37.
[54]	王晓红.微生物制药菌渣处理处置技术风险评价研究[D].哈尔滨:哈尔滨工业大学,2012.
[55]	李刚,邓伟年.发酵类抗生素制药菌渣焚烧处理设计[J].河南科技,2015(11):79-81.
[56]	张晓虹,王勤.某制药企业药渣洁净焚烧资源化处置的研究[J].杭州化工,2014,44(4):28-30.
[57]	郑向军,王薇,程兴军,等.MOD与焚烧技术联合处置抗生素菌渣的试验研究[J].环境工程技术学报,2018,8(4):406-412.
[58]	苗杨.青霉素菌渣风险评价体系及其管理体系框架构建研究[D].哈尔滨:哈尔滨工业大学,2014.
[59]	危险废物无害化处置技术线路[J].资源再生,2019(8):47-51.
[60]	王韶林.废弃物填埋处置场管理概述[J].云南环境科学,1996(2):21-23.