Abstract: Based on the combination of online monitoring and artificial water quality, this paper formulated a systematic monitoring scheme through collecting background data, and realized the quantitative analysis of pollutants load in the region. The results showed that in the "squeezing out water" working part of improving quality and efficiency strategy, the removal of groundwater infiltrated by sewage pipelines can increase the water quality concentration of sewage plants by 36.01%, playing an important role; the contribution rate of pollutant load of sewage from industrial enterprises was low, and some enterprises needed to continue to discharge into the sewage treatment plant after pretreatment; in the "sewage collection" working part, the scattered sewage in the urban-rural fringe areas had a great impact on the increase of water plants’ inlet concentration. After all the sewage is collected in pipes, the pollutants’ concentration of the sewage plant inlet will increase by 30.30%. At the same time, although the mixed flow sewage of rainwater pipe network and the leakage sewage of river crossing pipeline have little impact on the increase of the inlet pollutants concentration of sewage plant, the pipe still needs to be modified and even reconstructed.