Abstract: Drainage system is one of the important infrastructure in cities, and monitoring of its safe operation is of significant significance. To solve the problems of drainage system data management, online monitoring, business management, waterlogging warning, etc., taking Changzhou as the research object, the current situation and problems of its drainage system were analyzed in depth, and the solutions were given. Based on GIS, Internet of Things (IoT), artificial intelligence, digital twin and other technologies, the technical architecture of safe operation monitoring of drainage infrastructure was proposed, and momitoring platform for safe operation of drainage infrastructure in Changzhou were developed and applied. After the system went online, the maintenance cost of the pipeline network was reduced by 12% on average, the annual low water level operation time of sewage was increased by 10%, and the integrated scheduling efficiency of drainage was increased by 50%, so as to realize the whole life cycle management of facilities, all-round monitoring of pipe networks, urban flood prevention and emergency response, and integrated scheduling of source-network-plant-river. It effectively improves the digital and intelligent supervision level of drainage infrastructure in Changzhou, and can provide a reference for the safe operation monitoring of similar urban drainage infrastructures.