磺胺类抗生素的生物降解研究进展

白国敏; 孙寓姣; 孙钰洁; 任雪倩; 宣元焱; 刘美君; 云影

doi:10.13205/j.hjgc.202507013

磺胺类抗生素的生物降解研究进展

doi: 10.13205/j.hjgc.202507013

北京师范大学水科学研究院, 北京 100875

基金项目:

国家自然科学基金项目“光合细菌处理餐厨油脂废水及高价值物质合成回收的代谢调控机制研究”（52370065）

详细信息

作者简介:
白国敏（2001—），女，硕士，主要研究方向为环境微生物。baiguomin905@163.com

通讯作者:
孙寓姣（1975—），女，教授，主要研究方向为环境生物技术。sunyujiao@bnu.edu.cn

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- 文章访问数: 109
- HTML全文浏览量: 33
- PDF下载量: 2
- 被引次数: 0
出版历程
- 收稿日期: 2024-06-11
- 录用日期: 2024-08-08
- 修回日期: 2024-07-20
- 网络出版日期: 2025-09-11

Research progress on biodegradation of sulfonamides

College of Water Sciences, Beijing Normal University, Beijing 100875, China

摘要

摘要: 磺胺类抗生素作为一种广泛应用的抗菌药物，在增强病原菌耐药性及促进耐药基因的传播方面引起了研究的日益关注。生物降解对磺胺药物的耗散具有重要作用。文章综述了磺胺类抗生素在自然中的生物降解，并对相关的磺胺活性降解微生物种类进行综述，总结纯培养物和菌群的最佳降解条件。磺胺的生物降解受多因素控制，如温度、pH、药物初始浓度和外加碳源等。优化降解的运行条件，能够提高磺胺药物的去除效率。此外，许多研究分离出不同的降解菌属中存在高度相似的基因组，可能与其降解性能对应。不同的磺胺类型与降解菌属存在多种特定的代谢途径，与其携带的基因组相关。当前，磺胺类药物生物强化原位实践较少，其代谢途径和功能基因间存在的关系有待进一步研究。
- 磺胺类抗生素 /
- 微生物降解 /
- 控制条件 /
- 代谢途径
Abstract: Sulfonamides， a category of extensively utilized antibacterial medications， have attracted considerable attention due to their role in the escalation of drug resistance among pathogenic bacteria and the spread of drug resistance genes. Biodegradation plays a crucial role in the elimination of sulfonamides from the environment， serving as a natural barrier against the accumulation of these substances. This review provides an overview of the natural biodegradation of sulfonamides， exploring the microbial species involved in this process， and summarizes the optimal degradation conditions for both pure cultures and bacterial consortia. The biodegradation of sulfonamides is influenced by various factors， including temperature， pH， initial drug concentration， and the added carbon sources. Comprehending these factors is essential for optimizing degradation conditions， which can improve the efficiency of sulfonamide removal. Moreover， diverse sulfonamide-degrading bacteria have been observed to share highly similar genomes， which may correlate with their degradation efficiency. Different sulfonamide types exhibit distinct metabolic pathways with specific degrading bacterial genera， which are associated with their genomic characteristics. Currently， practices of bioaugmentation in situ for sulfonamides are still lacking， and the relationship between their metabolic pathways and functional genes requires further investigation.
- sulfonamides /
- microbial degradation /
- control conditions /
- metabolic pathway

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