RESEARCH PROGRESS ON HARMLESS AND RESOURCE UTILIZATION OF FERMENTATION RESIDUE OF STEROIDAL DRUGS

GUO Li-heng; GUAN Xiao-hong; LIU Hui-ling; DAI Xiao-hu

doi:10.13205/j.hjgc.202205034

Volume 40 Issue 5

Jul. 2022

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Article Navigation > ENVIRONMENTAL ENGINEERING > 2022 > 40(5): 244-250

GUO Li-heng, GUAN Xiao-hong, LIU Hui-ling, DAI Xiao-hu. RESEARCH PROGRESS ON HARMLESS AND RESOURCE UTILIZATION OF FERMENTATION RESIDUE OF STEROIDAL DRUGS[J]. ENVIRONMENTAL ENGINEERING , 2022, 40(5): 244-250. doi: 10.13205/j.hjgc.202205034

Citation:

GUO Li-heng, GUAN Xiao-hong, LIU Hui-ling, DAI Xiao-hu. RESEARCH PROGRESS ON HARMLESS AND RESOURCE UTILIZATION OF FERMENTATION RESIDUE OF STEROIDAL DRUGS[J]. ENVIRONMENTAL ENGINEERING , 2022, 40(5): 244-250. doi: 10.13205/j.hjgc.202205034

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RESEARCH PROGRESS ON HARMLESS AND RESOURCE UTILIZATION OF FERMENTATION RESIDUE OF STEROIDAL DRUGS

doi: 10.13205/j.hjgc.202205034

College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China

Received Date: 2021-04-27
Available Online: 2022-07-02

Abstract

Abstract

China is a major producer of steroidal APIs. The fermentation residue produced during the production of steroidal drugs by microbial transformation is a very valuable resource. However, there are still a small amount of toxic steroid residues in the fermentation residue, which is listed as national hazardous waste by the Ministry of Environmental Protection in China. At present, there are still some difficulties in the treatment of steroid drug fermentation residue, which has severely restricted the healthy development of pharmaceutical enterprises. For this reason, many researchers have conducted extensive research on the harmlessness and resource utilization of the residue. This paper starts with the source, pollution property and management requirements of steroid drug fermentation residue, and reviews its current research status and latest progress in the harmless and resource utilization, including pretreatment technologies such as hydrothermal treatment, alkali heat treatment and microwave treatment, resource utilization technologies such as fuel, fertilization and materialization, incineration, etc. The feasibility and operability of different treatment and disposal technologies were comprehensively analyzed, and finally the future research directions in this field were prospected.
- steroids,
- bacterial residue,
- harmless,
- resource utilization

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References(60)

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