RESEARCH PROGRESS ON REMOVAL OF ANTIBIOTICS AND ANTIBIOTIC RESISTANCE GENES FROM WASTEWATER BY CONSTRUCTED WETLANDS

LIU Linmei; TENG Yanguo; YANG Guang; CHEN Haiyang

doi:10.13205/j.hjgc.202212035

Volume 40 Issue 12

Nov. 2022

Turn off MathJax

Article Contents

Article Navigation > ENVIRONMENTAL ENGINEERING > 2022 > 40(12): 270-280

LIU Linmei, TENG Yanguo, YANG Guang, CHEN Haiyang. RESEARCH PROGRESS ON REMOVAL OF ANTIBIOTICS AND ANTIBIOTIC RESISTANCE GENES FROM WASTEWATER BY CONSTRUCTED WETLANDS[J]. ENVIRONMENTAL ENGINEERING , 2022, 40(12): 270-280. doi: 10.13205/j.hjgc.202212035

Citation:

LIU Linmei, TENG Yanguo, YANG Guang, CHEN Haiyang. RESEARCH PROGRESS ON REMOVAL OF ANTIBIOTICS AND ANTIBIOTIC RESISTANCE GENES FROM WASTEWATER BY CONSTRUCTED WETLANDS[J]. ENVIRONMENTAL ENGINEERING , 2022, 40(12): 270-280. doi: 10.13205/j.hjgc.202212035

Citation:

PDF( 18023 KB)

RESEARCH PROGRESS ON REMOVAL OF ANTIBIOTICS AND ANTIBIOTIC RESISTANCE GENES FROM WASTEWATER BY CONSTRUCTED WETLANDS

doi: 10.13205/j.hjgc.202212035

1. College of Water Science, Beijing Normal University, Beijing 100875, China;
2. Engineering Research Center of Groundwater Pollution Control and Remediation, Ministry of Education, Beijing 100875, China;
3. Harbin Water Supply Group Co., Ltd, Harbin 150070, China

Received Date: 2022-01-21
Available Online: 2023-03-23

Abstract

Abstract

Antibiotic contamination and the resulting resistance genes have attracted worldwide attention because of the extensive overuse and abuse of antibiotics, which seriously affects the environment as well as human health. This paper summarizes the latest progress in the removal of antibiotics and resistance genes from wastewater by constructed wetlands. Many studies showed that the removal rate of antibiotics in sewage by constructed wetland is generally 60% to 100%, and the removal rate of antibiotic resistance genes is generally 10% to 100%. The main influence factors of the removal of antibiotics and resistance genes in constructed wetland include seasonal variation, influent quality, hydraulic retention time, temperature, pH, microorganism, plant and substrate. The constructed wetlands incorporate biodegradation, adsorption, plant uptake, hydrolysis, and photodecomposition for antibiotics and antibiotic resistance genes. Although constructed wetland can remove antibiotics and resistance genes, the enrichment of antibiotics in the substrate and the increase of the abundance of effluent resistance genes will bring potential risks, which should be paid attention to. Further study should focus on the synergistic removal mechanism of antibiotics, resistance genes and traditional pollutants by constructed wetland, the removal mechanism and contribution of every part of constructed wetlands, as well as the newly constructed wetland treatment technologies coupled with bioelectrochemical systems.
- constructed wetlands,
- antibiotic,
- antibiotic resistance genes,
- removal,
- progress

FullText(HTML)

References(88)

References

[1]	SURETTE M D, WRIGHT G D. Lessons from the environmental antibiotic resistome[J]. Annual Review of Microbiology, 2017, 71:309-329.
[2]	DAVIES J, DAVIES D. Origins and evolution of antibiotic resistance[J]. Microbiology and Molecular Biology Reviews, 2010, 74(3):417-433.
[3]	RAVI S P, BALASUBRAMANIUM R. Antimicrobial resistance:global report on surveillance[J]. Australasian Medical Journal, 2014, 7(5):238-239.
[4]	LARRSON D G J, FLACH C F. Antibiotic resistance in the environment[J]. Nature Review in Microbiology, 2021, 20:257-269.
[5]	程羽霄,吴丹,陈铨乐,等.潮汐-复合流人工湿地系统优化及对抗生素抗性基因的去除效果[J].环境科学,2021,42(8):3799-3807.
[6]	RODRIGUEZ-MOZAZ S, VAZ-MOREIRA I, VAREL D G S, et al. Antibiotic residues in final effluents of European wastewater treatment plants and their impact on the aquatic environment[J]. Environment International, 2020, 140:105733.
[7]	MUNIR M, WONG K, XAGORARAKI I. Release of antibiotic-resistant bacteria and genes in the effluent and biosolids of five wastewater utilities in Michigan[J]. Water Research, 2011, 45(2):681-693.
[8]	ZHUAN M, ACHMON Y, CAO Y P, et al. Distribution of antibiotic resistance genes in the environment[J]. Environmental Pollution, 2021, 285:117402.
[9]	DONG P Y, WANG H, FANG T T, et al. Assessment of extracellular antibiotic resistance genes (eARGs) in typical environmental samples and the transforming ability of eARG[J]. Environment International, 2019, 125:90-96.
[10]	WU Y, CUI E P, ZUO Y R, et al. Fate of antibiotic and metal resistance genes during two-phase anaerobic digestion of residue sludge revealed by metagenomic approach[J]. Environmental Science and Pollution Research,2018, 25:13956-13963.
[11]	CACACE D, FATTA-KASSINOS D, MANAIA C M, et al. Antibiotic resistance genes in treated wastewater and in the receiving water bodies:a pan-European survey of urban settings[J]. Water Research, 2019, 162:320-330.
[12]	PALLARES-VEGA R, BLAAK H, van DER PLAATS R, et al. Determinants of presence and removal of antibiotic resistance genes during WWTP treatment:a cross-sectional study[J]. Water Research, 2019, 161:319-328.
[13]	PÄRNÄNEN K M M, NARCISO-DA-ROCHA C, KNEIS D, et al. Antibiotic resistance in European wastewater treatment plants mirrors the pattern of clinical antibiotic resistance prevalence[J]. Science Advance, 2019, 5(3):eaau9124.
[14]	HENDRIKSEN R S, MUNK P, NJAGE P, et al. Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage[J]. Nature Communication, 2019, 10:1124.
[15]	NAQUIN A, SHRESTHA A, SHERPA M, et al. Presence of antibiotic resistance genes in a sewage treatment plant in Thibodaux, Louisiana, USA[J]. Bioresource Technology, 2015, 188:79-83.
[16]	BOUGNOM B P, MCNALLY A, ETOA F X, et al. Antibiotic resistance genes are abundant and diverse in raw sewage used for urban agriculture in Africa and associated with urban population density[J]. Environmental Pollution, 2019, 251:146-154.
[17]	HAMIWE T, KOCK M M, MAGWIRA C A, et al. Occurrence of enterococci harbouring clinically important antibiotic resistance genes in the aquatic environment in Gauteng, South Africa[J]. Environmental Pollution, 2019, 245:1041-1049.
[18]	KADLEC R H. The inadequacy of first-order treatment wetland models[J]. Ecological Engineering, 2000, 15(1/2):105-109.
[19]	VYMAZAL J. Constructed wetlands for wastewater treatment:five decades of experience[J]. Environmental Science and Technology, 2011, 45(1):61-69.
[20]	HE Y J, ZHANG L, JIANG L X, et al. Improving removal of antibiotics in constructed wetland treatment systems based on key design and operational parameters:a review[J]. Journal of Hazardous Materials, 2021, 407:124386.
[21]	SEMERARO T, GIANNUZZI C, BECCAISI L, et al. Constructed treatment wetland as an opportunity to enhance biodiversity and ecosystem services[J]. Ecological Engineering, 2015, 82:517-526.
[22]	LIU R B, ZHAO Y Q, DOHERTY L, et al. A review of incorporation of constructed wetland with other treatment processes[J]. Chemical Engineering Journal, 2015, 279:220-230.
[23]	GIZÍNSKA-GÓRNA M, CZEKALA W, JÓZWIAKOWSKI K, et al. The possibility of using plants from hybrid constructed wetland wastewater treatment plant for energy purposes. Ecological Engineering, 2016, 95:534-541.
[24]	GHRABI A, BOUSSELMI L, MASI F, et al. Constructed wetland as a low cost and sustainable solution for wastewater treatment adapted to rural settlements:the chorfech wastewater treatment pilot plant[J]. Water Science and Technology, 2011, 63:3006-3012.
[25]	WU S B, WALLACE S, BRIX H, et al. Treatment of industrial effluents in constructed wetlands:challenges, operational strategies and overall performance[J]. Environmental Pollution, 2015, 201:107-120.
[26]	DOHERTY L, ZHAO Y, ZHAO X, et al. A review of a recently emerged technology:constructed wetland-microbial fuel cells[J]. Water Research, 2015, 85:38-45.
[27]	LIU D, WU X, CHANG J, et al. Constructed wetlands as biofuel production systems[J]. Nature Climate Change, 2012, 2:190-194.
[28]	LIU X H, GUO X C, LIU Y, et al. A review on removing antibiotics and antibiotic resistance genes from wastewater by constructed wetlands:performance and microbial response[J]. Environmental Pollution, 2019, 254:112996.
[29]	BERGLUND B, ALI KHAN G, WEISNER S E B, et al. Efficient removal of antibiotics in surface-flow constructed wetlands, with no observed impact on antibiotic resistance genes[J]. Science of the Total Environment, 2014, 476/477:29-37.
[30]	KADLLEC R H, WALLACE S D. Treatment wetlands[M]. 2nd ed. USA:CRC Press, 2008:232-287.
[31]	PARDE D, PATWA A, SHUKLA A, et al. A review of constructed wetland on type, treatment and technology of wastewater[J]. Environmental Technology & Innovation, 2021, 21:101261.
[32]	FANG H S, ZHANG Q, NIE X P, et al. Occurrence and elimination of antibiotic resistance genes in a longterm operation integrated surface flow constructed wetland[J]. Chemosphere, 2017, 173:99-106.
[33]	WU H M, ZHANG J, NGO H H, et al. A review on the sustainability of constructed wetlands for wastewater treatment:design and operation[J]. Bioresources Technology, 2015, 175:594-601.
[34]	ZHANG D Q, GERSBERG R M, KEAT T S. Constructed wetlands in China[J]. Ecological Engineering, 2009, 35:1367-1378.
[35]	OHORE O E, QIN Z, SANGANYADO E, et al. Ecological impact of antibiotics on bioremediation performance of constructed wetlands:microbial and plant dynamics, and potential antibiotic resistance genes hotspots[J]. Journal of Hazardous Materials, 2022, 424:127495.
[36]	张金璐. 表面流人工湿地对养殖废水中抗生素和抗性基因去除效应研究[D]. 长沙:湖南农业大学,2017.
[37]	LIU L, LIU Y H, WANG Z, et al. Behavior of tetracycline and sulfamethazine with corresponding resistance genes from swine wastewater in pi-lot-scale constructed wetlands[J]. Journal of Hazardous Materials, 2014, 278:304-310.
[38]	HUANG X, LIU C X, LI K, et al. Performance of vertical up-flow constructed wetlands on swine wastewater containing tetracyclines and tert genes[J]. Water Research, 2015, 70:109-117.
[39]	ÁVILA C, GARCÍA-GALÁN M J, BORREGO C M, et al. New insights on the combined removal of antibiotics and ARGs in urban wastewater through the use of two configurations of vertical subsurface flow constructed wetlands[J]. Science of the Total Environment, 2021, 755:142554.
[40]	HIJOSA-VALSERO M, SIDRACH-CARDONA R, MARTÍN-VILLACORTA J, et al. Statistical modelling of organic matter and emerging pollutants removal in constructed wetlands[J]. Bioresource Technology, 2011, 102:4981-4988.
[41]	LIU L, LIU C X, ZHENG J Y, et al. Elimination of veterinary antibiotics and antibiotic resistance genes from swine wastewater in the vertical flow constructed wetlands[J]. Chemosphere, 2013, 91:1088-1093.
[42]	阿丹. 人工湿地对14种常用抗生素的去除效果及影响因素研究[D]. 广州:暨南大学,2012.
[43]	HUANG X, ZHENG J L, LIU C X, et al. Removal of antibiotics and resistance genes from swine wastewater using vertical flow constructed wetlands:effect of hydraulic flow direction and substrate type[J]. Chemical Engineering Journal, 2017, 308:692-699.
[44]	ZHANG C H, NING K, ZHANG W W, et al. Determination and removal of antibiotics in secondary effluent using a horizontal subsurface flow constructed wetland[J]. Environmental Science Processes & Impacts, 2013, 15(4):79-714.
[45]	CHEN J, DENG W J, LIU Y S, et al. Fate and removal of antibiotics and antibiotic resistance genes in hybrid constructed wetlands[J]. Environmental Pollution, 2019, 249:894-903.
[46]	CHOI Y J, KIM L H, ZOH K D. Removal characteristics and mechanism of antibiotics using constructed wetlands[J]. Ecological Engineering, 2016, 91:85-92.
[47]	LIU L, LIU Y H, WANG Z, et al. Behavior of tetracycline and sulfamethazine with corresponding resistance genes from swine wastewater in pilot-scale constructed wetlands[J]. Journal of Hazardous Materials, 2014, 278:304-310.
[48]	XIAN Q M, HU L X, CHEN H C, et al. Removal of nutrients and veterinary antibiotics from swine wastewater by a constructed macrophyte floating bed system[J]. Journal of Environmental Management, 2010, 91:2657-2661.
[49]	HUSSAIN S A, PRASHER S O, PATEL M. Removal of ionophoric antibiotics in free water surface constructed wetlands[J]. Ecological Engineering, 2021, 41:13-21.
[50]	REYES-CONTREREA C, MATAMOROS V, RUIZ I, et al. Evaluation of PPCPs removal in a combined anaerobic digester-constructed wetland pilot plant treating urban wastewater[J]. Chemosphere, 2011, 84:1200-1207.
[51]	CHEN J, YING G G, WEI X D, et al. Removal of antibiotics and antibiotic resistance genes from domestic sewage by constructed wetlands:effect of flow configuration and plant species[J]. Science of the Total Environment, 2016, 571:974-982.
[52]	ABOU-KANDIL A, SHIBLI A, AZAIZEH H, et al. Fate and removal of bacteria and antibiotic resistance genes in horizontal subsurface constructed wetlands:effect of mixed vegetation and substrate type[J]. Science of the Total Environment, 2021, 759:144193.
[53]	DU J P, XU T, GUO X P, et al. Characteristics and removal of antibiotics and antibiotic resistance genes in a constructed wetland from a drinking water source in the Yangtze River Delta[J]. Science of the Total Environment, 2022, 813:152540.
[54]	张子扬,刘舒巍,张璐. 人工湿地去除畜禽养殖废水中磺胺类抗生素抗性基因研究[J]. 环境科学与管理,2016,41(5):89-92.
[55]	YI X, TRAN N H, YIN T, et al. Removal of selected PPCPs, EDCs, and antibiotic resistance genes in landfill leachate by a full-scale constructed wetlands system[J]. Water Research, 2017, 121:46-60.
[56]	CHEN J, LIU Y S, SU H C, et al. Removal of antibiotics and antibiotic resistance genes in rural wastewater by an integrated constructed wetland[J]. Environmental Science and Pollution Research, 2015, 22:1794-1803.
[57]	NÖLVAK H, TRUU M, TIIRIK K, et al. Dynamics of antibiotic resistance genes and their relationships with system treatment efficiency in a horizontal subsurface flow constructed wetland[J]. Science of the Total Environment, 2013, 461/462:636-644.
[58]	DU L, ZHAO Y Q, WANG C, et al. Removal performance of antibiotics and antibiotic resistance genes in swine wastewater by integrated vertical-flow constructed wetlands with zeolite substrate[J]. Science of the Total Environment, 2020, 721:137765.
[59]	HE Y J, NURUL S, SCHMITT H, et al. Evaluation of attenuation of pharmaceuticals, toxic potency, and antibiotic resistance genes in constructed wetlands treating wastewater effluents[J]. Science of the Total Environment, 2018, 631/632:1572-1581.
[60]	VIVANT A L, BOUTIN C, PROST-BOUCLE S, et al. Free water surface constructed wetlands limit the dissemination of extended-spectrum beta-lactamase producing Escherichia coli in the natural environment[J]. Water Research, 2016, 104:178-188.
[61]	DAN A, YANG Y, DAI Y N, et al. Removal and factors influencing removal of sulfonamides and trimethoprim from domestic sewage in constructed wetlands[J]. Bioresource Technology, 2013, 146:363-370.
[62]	LI S, ZHANG R J, HU J R, et al. Occurrence and removal of antibiotics and antibiotic resistance genes in natural and constructed riverine wetlands in Beijing, China[J]. Science of the Total Environment, 2019, 664:546-553.
[63]	CHRISTOFILOPOULOS S, KALIAKATSOS A, TRIANTAFYLLOU K, et al. Evaluation of a constructed wetland for wastewater treatment:addressing emerging organic contaminants and antibiotic resistant bacteria[J]. New Biotechnology, 2019, 52:94-103.
[64]	MATAMOROS V, CASELLES-OSORIO A, GARCIA J, et al. Behaviour of pharmaceutical products and biodegradation intermediates in horizontal subsurface flow constructed wetland:a microcosm experiment[J]. Science of the Total Environment, 2008, 394:171-176.
[65]	GUAN Y D, WANG B, GAO Y X, et al. Occurrence and fate of antibiotics in the aqueous environment and their removal by constructed wetlands in China:a review[J]. Pedosphere, 2017, 27:42-51.
[66]	CONKLE J L, LATTAO C, WHITE J R, et al. Competitive sorption and desorption behavior for three fluoroquinolone antibiotics in a wastewater treatment wetland soil[J]. Chemosphere, 2010, 80(11):1353-1359.
[67]	SABRI N, SCHMITT H, VAN DER ZAAN B M, et al. Performance of full scale constructed wetlands in removing antibiotics and antibiotic resistance genes[J]. Science of the Total Environment, 2021,786:147368.
[68]	KADLEC R H, WALLACE S D. Treatment wetlands[M]. Boca Raton:Taylor and Francis, 2009, 2-20.
[69]	LECLERCQ S O, WANG C, SUI Z H, et al. A multiplayer game:species of Clostridium, Acinetobacter, and Pseudomonas are responsible for the persistence of antibiotic resistance genes in manure-treated soils[J]. Environmental Microbiology, 2016, 18:3494-3508.
[70]	程宪伟,粱银秀,祝惠,等. 人工湿地处理水体中抗生素的研究进展[J]. 湿地科学,2017,15(1):125-131.
[71]	VACCA G, WAND H, NIKOLAUSZ M, et al. Effect of plants and filter materials on bacteria removal in pilot-scale constructed wetlands[J]. Water Research, 2005, 39:1361-1373.
[72]	李泽兵,韩飞,曾圣男,等. 人工湿地去除养殖废水中磺胺类抗生素的影响因素研究进展[J]. 生态毒理学报,2020,15(5)49-58.
[73]	LI Y F, ZHU G B, NG W J, et al. A review on removing pharmaceuticals contaminants from wastewater by constructed wetlands:design, performance and mechanism[J]. Science of the Total Environment, 2014, 468/469:908-932.
[74]	OHORE O E, ZHANG S H, GUO S Z, et al. The fate of tetracycline in vegetated mesocosmic wetlands and its impact on the water quality and epiphytic microbes[J]. Journal of Hazardous Material, 2021, 417:126148.
[75]	DORDIO A V, CARVALHO A J P. Organic xenobiotics removal in constructed wetlands, with emphasis on the importance of the support matrix[J]. Journal of Hazardous Material, 2013, 252/253:272-292.
[76]	HE Y J, NURUL S, SCHMITT H, et al. Evaluation of attenuation of pharmaceuticals, toxic potency, and antibiotic resistance genes in constructed wetlands treating wastewater effluents[J]. Science of the Total Environment, 2018, 631/632:1572-1581.
[77]	LI B, ZHANG T. Biodegradation and adsorption of antibiotics in the activated sludge process[J]. Environmental Science and Technology, 2010, 44:3468-3473.
[78]	PÉREZ S, EICHHORN P, AGA D S. Evaluating the biodegradability of sulfamethazine, sulfamethoxazole, sulfathiazole, and trimethoprim at different stages of sewage treatment[J]. Environmental Toxicology and Chemistry, 2005, 24:1361-1367.
[79]	JIANG M X, WANG L H, JI R. Biotic and abiotic degradation of four cephalosporin antibiotics in a lake surface water and sediment[J]. Chemosphere, 2010, 80:1399-1405.
[80]	KUMMERER K. Antibiotics in the aquatic environment:a review-part Ⅰ[J]. Chemosphere, 2009, 75:417-434.
[81]	RVHMLAND S, WICK A, TERNES T A, et al. Fate of pharmaceuticals in a subsurface flow constructed wetland and two ponds[J]. Ecological Engineering, 2015, 80:125-139.
[82]	LIU Y, LIU X, LU S, et al. Adsorption and biodegradation of sulfamethoxazole and ofloxacin on zeolite:influence of particle diameter and redox potential[J]. Chemical Engineering Journal, 2020, 384:123346.
[83]	CHEN M, ZHU X, ZHU Y, et al. Collision of emerging and traditional methods for antibiotics removal:taking constructed wetlands and nanotechnology as an example[J]. Nano Impact, 2019, 15:100175.
[84]	PILON-SMITS E. Phytoremediation[J]. Annual Review Plant Biology, 2005, 56:15-39.
[85]	MATHEWS S, REINHOLD D. Biosolid-borne tetracyclines and sulfonamides in plants[J]. Environmental Science and Pollution Research, 2013, 20, 4327-4338.
[86]	郑加玉,刘琳,高大文,等. 四环素抗性基因在人工湿地中的去除及累积[J]. 环境科学,2013,34(8):3102-3107.
[87]	ANDERSON J C, CARLSON J C, LOW J E, et al. Performance of a constructed wetland in Grand Marais, Manitoba, Canada:removal of nutrients, pharmaceuticals, and antibiotic resistance genes from municipal wastewater[J]. Chemistry Central Journal, 2013, 7(54):1-15.
[88]	CHEN P, GUO X, LI S, et al. A review of the bioelectrochemical system as an emerging versatile technology for reduction of antibiotic resistance genes[J]. Environment International, 2021, 156:106689.