OCCURRENCE AND RISK ASSESSMENT OF ANTIBIOTICS IN GROUNDWATER ENVIRONMENT IN CHINA

KONG Huimin; ZHAO Xiaohui; XU Wan; DAI Yuhan; ZHANG Jiayu

doi:10.13205/j.hjgc.202302029

Volume 41 Issue 2

Feb. 2023

Turn off MathJax

Article Contents

Abstract

References

Article Navigation > ENVIRONMENTAL ENGINEERING > 2023 > 41(2): 219-226

KONG Huimin, ZHAO Xiaohui, XU Wan, DAI Yuhan, ZHANG Jiayu. OCCURRENCE AND RISK ASSESSMENT OF ANTIBIOTICS IN GROUNDWATER ENVIRONMENT IN CHINA[J]. ENVIRONMENTAL ENGINEERING , 2023, 41(2): 219-226. doi: 10.13205/j.hjgc.202302029

Citation:

KONG Huimin, ZHAO Xiaohui, XU Wan, DAI Yuhan, ZHANG Jiayu. OCCURRENCE AND RISK ASSESSMENT OF ANTIBIOTICS IN GROUNDWATER ENVIRONMENT IN CHINA[J]. ENVIRONMENTAL ENGINEERING , 2023, 41(2): 219-226. doi: 10.13205/j.hjgc.202302029

Citation:

PDF( 1334 KB)

OCCURRENCE AND RISK ASSESSMENT OF ANTIBIOTICS IN GROUNDWATER ENVIRONMENT IN CHINA

doi: 10.13205/j.hjgc.202302029

1. Institute of Engineering Mechanics, China Earthquake Administration, Harbin 150080, China;
2. Institute of Disaster Prevention, Sanhe 065201, China;
3. Department of Water Ecology and Environment, China Institute of Water Resources and Hydropower Research, Beijing 100038, China

Received Date: 2021-12-21
Available Online: 2023-05-25
Publish Date: 2023-02-01

Abstract

Abstract

Occurrence of antibiotics in groundwater environment of major cities in China was explored based on the integration of the research results in recent 10 years, and the ecological risks and health risks of typical antibiotics were evaluated based on risk quotient method. The results showed that:1)in groundwater of major cities in China, a total of 57 types of antibiotics belonging to 7 categories were detected. Sulfa and quinolones were the main pollutants, with the most types in high cumulative concentration, followed by macrolides and tetracycline; 2) sulfamethoxazole, sulfathiazole and clindamycin had high ecological risk in groundwater environment. The combined ecological risk of groundwater antibiotics in northern cities was higher than that in southern cities, in which quinolone, sulfa and tetracycline were the three categories of antibiotics with high ecological risk rates and in the largest proportion contributing to the urban groundwater ecological risk;3) in the present, the investigated antibiotics did not appear to pose direct human health risk through drinking water based on health risk quotient method.
- groundwater,
- antibiotics,
- occurrence,
- ecological risk assessment,
- health risk assessment

FullText(HTML)

References(47)

References

[1]	丁惠君. 鄱阳湖水环境抗生素污染特征及典型抗生素的吸附和降解研究[D]. 武汉:武汉大学, 2018.
[2]	章琴琴. 北京温榆河流域抗生素污染分布特征及源解析研究[D]. 重庆:重庆大学, 2012.
[3]	卫毅梅. 抗生素在城市河流中的污染特征及生态毒性研究[D]. 沈阳:辽宁大学, 2013.
[4]	李佳乐. 污灌区土壤-地下水系统中典型有机污染物的环境地球化学研究[D]. 北京:中国地质大学, 2015.
[5]	HU X G, ZHOU Q X, LUO Y. Occurrence and source analysis of typical veterinary antibiotics in manure, soil, vegetables and groundwater from organic vegetable bases, northern China[J]. Environmental Pollution, 2010,158(9):2992-2998.
[6]	ZHOU L J, YING G G, LIU S, et al. Simultaneous determination of human and veterinary antibiotics in various environmental matrices by rapid resolution liquid chromatography-electrospray ionization tandem mass spectrometry[J]. Journal of Chromatography A, 2012,1244:123-138.
[7]	戴刚, 徐浩, 杨琼, 等. 毕节垃圾场周边水源中抗生素污染特征[J]. 环境科学与技术, 2015,38(增刊2):263-268.
[8]	陈琼, 丁惠君, 张维昊, 等. 滨湖底泥对2种喹诺酮类抗生素的吸附作用研究[J]. 环境科学与技术, 2019,42(6):106-114.
[9]	苏思慧, 何江涛, 杨蕾, 等. 北京东南郊土壤剖面氟喹诺酮类抗生素分布特征[J]. 环境科学, 2014,35(11):4257-4266.
[10]	廖杰, 魏晓琴, 肖燕琴, 等. 莲花水库水体中抗生素污染特征及生态风险评价[J]. 环境科学, 2020,41(9):4081-4087.
[11]	王娅南, 黄合田, 彭洁, 等. 贵州草海喀斯特高原湿地水环境中典型抗生素的分布特征[J]. 环境化学, 2020,39(4):975-986.
[12]	刘锋, 应光国, 周启星, 等. 抗生素类药物对土壤微生物呼吸的影响[J]. 环境科学, 2009,30(5):1280-1285.
[13]	赵富强, 高会, 张克玉, 等. 中国典型河流水域抗生素的赋存状况及风险评估研究[J]. 环境污染与防治, 2021,43(1):94-102.
[14]	CHEN L, LANG H, LIU F, et al. Presence of antibiotics in shallow groundwater in the northern and southwestern regions of China[J]. Groundwater, 2018,56(3):451-457.
[15]	YAO L L, WANG Y X, TONG L, et al. Occurrence and risk assessment of antibiotics in surface water and groundwater from different depths of aquifers:a case study at Jianghan Plain, central China[J]. Ecotoxicology and Environmental Safety, 2017,135:236-242.
[16]	MA Y P, LI M, WU M M, et al. Occurrences and regional distributions of 20 antibiotics in water bodies during groundwater recharge[J]. Science of the Total Environment, 2015,518/519:498-506.
[17]	陈卫平, 彭程伟, 杨阳, 等. 北京市地下水中典型抗生素分布特征与潜在风险[J]. 环境科学, 2017,38(12):5074-5080.
[18]	FU C X, XU B T, CHEN H, et al. Occurrence and distribution of antibiotics in groundwater, surface water, and sediment in Xiong'an New Area, China, and their relationship with antibiotic resistance genes[J]. Science of the Total Environment, 2021,807:151011.
[19]	剧泽佳, 赵鑫宇, 陈慧, 等. 石家庄市水环境中喹诺酮类抗生素的空间分布特征与环境风险评估[J]. 环境科学学报, 2021,41(12):4919-4931.
[20]	马建生, 王卓, 张泽宇. 哈尔滨市地下水中29种抗生素分布特征研究[J]. 岩矿测试, 2021,40(6):944-953.
[21]	European C. Technical guidance document in support of commission directive 93/67/EEC on risk assessment for new notified substances[J]. Commission Regulation (EC):No 1488/94 on Risk Assessment for Existing Substance Part Ⅱ,2003:100-103.
[22]	CLEUVERS M. Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects[J]. Toxicology Letters, 2003,142(3):185-194.
[23]	CLEUVERS M. Mixture toxicity of the anti-inflammatory drugs diclofenac, ibuprofen, naproxen, and acetylsalicylic acid[J]. Ecotoxicology and Environmental Safety,2004,59(3):309-315.
[24]	PARK S, CHOI K. Hazard assessment of commonly used agricultural antibiotics on aquatic ecosystems[J]. Ecotoxicology,2008,17(6):526-538.
[25]	RODRIGUEZ-MOZAZ S, VAZ-MOREIRA I, VARELA DELLA GIUSTINA S, et al. Antibiotic residues in final effluents of European wastewater treatment plants and their impact on the aquatic environment[J]. Environmental International, 2020, 140, 105733.
[26]	HALLING-SØRENSEN B, HOLTEN LVTZHØFT H C, ANDERSEN H R, et al. Environmental risk assessment of antibiotics:comparison of mecillinam, trimethoprim and ciprofloxacin[J]. Journal of Antimicrobial Chemotherapy, 2000, 46(suppl_1):53-58.
[27]	BENOT F, RAPHAEL M, BERNARD V, et al. Environmental risk assessment of six human pharmaceuticals:are the current environmental risk assessment procedures sufficient for the protection of the aquatic environment[J]. Environmental Toxicology and Chemistry, 2009, 23(5):1344-1354.
[28]	TELL J, CALDWELL D J, HANER A, et al. Science-based targets for antibiotics in receiving waters from pharmaceutical manufacturing operations[J]. Integrated Environmental Assessment and Management, 2019, 15(3):312-319.
[29]	LIU Y, FENG M, WANG B, et al. Distribution and potential risk assessment of antibiotic pollution in the main drinking water sources of Nanjing, China[J]. Environmental Science and Pollution Research, 2020, 27(17):21429-21441.
[30]	LIU X, LU S,GUO W, et al. Antibiotics in the aquatic environments:a review of lakes,China[J]. Sci Total Environ, 2018, 627:1195-1208.
[31]	HOLTEN LU··TZHØFT H C, HALLING-SØRENSEN B, JØRGENSEN S E. Toxicity of antibacterial agents applied in danish fish farming[J]. Archives of Environmental Contamination and Toxicology, 1999,36:1-6.
[32]	QIN L T, PANG X R, ZENG H H, et al. Ecological and human health risk of sulfonamides in surface water and groundwater of Huixian karst wetland in Guilin, China[J]. Science of the Total Environment, 2020, 708:134552.
[33]	DE LIGUORO M, DI LEVA V, GALLINA G, et al. Evaluation of the aquatic toxicity of two veterinary sulfonamides using five test organisms[J]. Chemosphere, 2010, 81(6):788-793.
[34]	IM J K, KIM S H, NOH H R, et al. Temporal-spatial variation and environmental risk assessment of pharmaceuticals in tributaries of the Han River watershed, South Korea[J]. Science of the Total Environment, 2020, 741:140486.
[35]	SCHWAB B W, HAYES E P, FIORI J M, et al. Human pharmaceuticals in US surface waters:a human health risk assessment[J]. Regulatory Toxicology and Pharmacology, 2005, 42(3):296-312.
[36]	BOOTH A, AGA D S, WESTER A L. Retrospective analysis of the global antibiotic residues that exceed the predicted no effect concentration for antimicrobial resistance in various environmental matrices[J]. Environmental International, 2020,141:105796.
[37]	GARCIA-GALAN M J, DIAZ-CRUZ M S, BARCELO D. Occurrence of sulfonamide residues along the Ebro River basin:removal in wastewater treatment plants and environmental impact assessment[J]. Environmental International, 2011, 37(2):462-473.
[38]	LI N, ZHANG X, WU W, et al. Occurrence, seasonal variation and risk assessment of antibiotics in the reservoirs in North China[J]. Chemosphere, 2014,111:327-335.
[39]	MADUREIRA T V, CRUZEIRO C, ROCHA M J, et al. The toxicity potential of pharmaceuticals found in the Douro River estuary (Portugal):experimental assessment using a zebrafish embryo test[J]. Environmental Toxicology and Pharmacology, 2011,32(2):212-217.
[40]	HUANG D J, HOU J H, KUO T F, et al. Toxicity of the veterinary sulfonamide antibiotic sulfamonomethoxine to five aquatic organisms[J]. Environmental Toxicology and Pharmacology, 2014, 38(3):874-880.
[41]	CHOI K, KIM Y, PARK J, et al. Seasonal variations of several pharmaceutical residues in surface water and sewage treatment plants of Han River, Korea[J]. Science of the Total Environment, 2008, 405(1/2/3):120-128.
[42]	LI S, SHI W Z, LI H M, et al. Antibiotics in water and sediments of rivers and coastal area of Zhuhai City, Pearl River estuary, south China[J]. Science of the Total Environment, 2018, 636:1009-1019.
[43]	LU S, LIN C Y, LEI K, et al. Occurrence, spatiotemporal variation, and ecological risk of antibiotics in the water of the semi-enclosed urbanized Jiaozhou Bay in eastern China[J]. Water Research, 2020, 184:116187.
[44]	HANNA N, SUM P, SUN Q, et al. Presence of antibiotic residues in various environmental compartments of Shandong province in eastern China:its potential for resistance development and ecological and human risk[J]. Environmental International, 2018, 114:131-142.
[45]	WANG H X, YANG J Q, YU X, et al. Exposure of adults to antibiotics in a shanghai suburban area and health risk assessment:a biomonitoring-based study[J]. Environmental Science &Technology, 2018, 52(23):13942-13950.
[46]	US EPA. Fact Sheet:Methodology for Deriving Ambient Water Quality Criteria for the Protection of Human Health-Revised Methodology (2000)[Z/OL]. 2000. URL. https://www.epa.gov/wqc/fact-sheet-methodology-deriving-ambient-water-quality-criter-iaprotection-human-health-revised.
[47]	World Health Organization. Guidelines for Drinking Water Quality[M/OL]. 4th ed. Geneva 2001. WHO. URL. http://www.who.int/water_sanitation_health/publications/2011/dwq_guidelines/en/.

Relative Articles

[1]	CUI Qian, ZHOU Zhixiang, GUAN Dongjie, XUE Yuqian. Research progress on accounting, modeling and influencing factors of transportation carbon emissions[J]. ENVIRONMENTAL ENGINEERING , 2025, 43(1): 31-41. doi: 10.13205/j.hjgc.202501004
[2]	ZHENG Xiaoying, LI Wenfei, ZHANG Huijie, HU Ruijie, XU Yadong, HAN Zongshuo, HE Haidong, CHEN Wei. RESEARCH ON ENDOGENOUS PARTIAL DENITRIFICATION GRANULAR SLUDGE CULTIVATION AND KEY INFLUENCING FACTORS[J]. ENVIRONMENTAL ENGINEERING , 2024, 42(9): 116-123. doi: 10.13205/j.hjgc.202409011
[3]	LI Cheng, LU Binbin, YI Xinyuan, SHAO Xuehong, XU Bin, TANG Yulin. CARBON EMISSION CHARACTERISTICS AND INFLUENCING FACTORS OF TYPICAL WATER SUPPLY PLANTS IN SHANGHAI BASED ON MONTHLY DATA[J]. ENVIRONMENTAL ENGINEERING , 2024, 42(11): 131-139. doi: 10.13205/j.hjgc.202411014
[4]	HE Kaijie, HE Youjiang, YANG Xin, CHENG Miaomiao, LI Fuqiang, PENG Yujie, LI Bin. CHARACTERISTICS AND INFLUENCING FACTORS OF ATMOSPHERIC NH₃ POLLUTION IN SHIHEZI[J]. ENVIRONMENTAL ENGINEERING , 2024, 42(7): 162-170. doi: 10.13205/j.hjgc.202407018
[5]	HE Zihao, YI Mengting, ZHONG Qiumeng, LIANG Sai. INFLUENCING FACTORS OF SYNERGY DEGREE FOR INDUSTRIAL POLLUTANT AND CARBON REDUCTIONS IN CHINESE CITIES[J]. ENVIRONMENTAL ENGINEERING , 2024, 42(1): 206-214. doi: 10.13205/j.hjgc.202401027
[6]	REN Hongyang, DU Ruolan, XIE Guilin, JIN Wenhui, LI Xi, DENG Yuanpeng, MA Wei, WANG Bing. RESEARCH STATUS OF INFLUENCING FACTORS AND IDENTIFICATION METHODS OF CARBON EMISSIONS IN CHINA[J]. ENVIRONMENTAL ENGINEERING , 2023, 41(10): 195-203,244. doi: 10.13205/j.hjgc.202310023
[7]	YUAN Ye, GAO Jun, ZHANG Lulu, CHEN Tianming, DING Cheng. RESEARCH PROGRESS ON INFLUENCING FACTORS AND THEIR PREDICTION MODELS OF HYDROGEN SULFIDE GENERATION IN MUNICIPAL SEWAGE PIPELINES[J]. ENVIRONMENTAL ENGINEERING , 2023, 41(11): 69-77. doi: 10.13205/j.hjgc.202311013
[8]	MA Yan, ZHANG Dading, ZHANG Fan, CHENG Lu, MA Yue, GUO Jianda. INFLUENTING FACTORS OF CHITOSAN-MODIFIED ZEOLITE AND ITS STABILIZATION EFFECT ON MULTI METAL CONTAMINATED SOIL[J]. ENVIRONMENTAL ENGINEERING , 2022, 40(1): 94-101,116. doi: 10.13205/j.hjgc.202201014
[9]	CHEN Yue, PAN Yang, NI Min, HUANG Yong, LI Da-peng, BI Zhen, ZHANG Xing-yu, WEN Lin-xiao. ANALYSIS OF INFLUENCING FACTORS OF PHOSPHATE ENHANCED ABSORPTION IN BSBR PROCESS UNDER LOW CARBON SOURCE CONDITIONS[J]. ENVIRONMENTAL ENGINEERING , 2022, 40(9): 69-73,191. doi: 10.13205/j.hjgc.202209009
[10]	TANG Xin-yi, CHEN Xiang-yu, XIAO Ben-yi, LIU Rong-zhan. THERMAL-ALKALINE TREATMENT OF SEWAGE SLUDGE AND ITS ENHANCEMENT ON ANAEROBIC SLUDGE DIGESTION[J]. ENVIRONMENTAL ENGINEERING , 2022, 40(5): 218-226. doi: 10.13205/j.hjgc.202205031
[11]	XU Ziqi, YAN Zhong, GE Yanju, WEI Quanyuan, HUANG Bo. OPTIMIZATION OF TECHNICAL PARAMETERS OF MECHANICAL ENHANCED RAPID COMPOSTING TECHNOLOGY FOR ORGANIC SOLID WASTE[J]. ENVIRONMENTAL ENGINEERING , 2022, 40(8): 159-163,142. doi: 10.13205/j.hjgc.202208022
[12]	CHEN Si-yu, ZHANG Shao-qing, CHEN Peng, CHEN Qiu-li, ZHANG Li-qiu, LI Shu-geng. RECENT ADVANCES IN PARTIAL DENITRIFICATION BASED BIOLOGICAL NITROGEN REMOVAL[J]. ENVIRONMENTAL ENGINEERING , 2021, 39(5): 38-44. doi: 10.13205/j.hjgc.202105006
[13]	XU Chuang, WU Yin-hu, HU Hong-ying, XU Ao, NI Xin-ye. CHLORINE DIOXIDE'S INACTIVATION ON DIFFERENT MICROORGANISMS AND ITS INFLUENCE ON THE CHARACTERISTICS OF MICROBIAL COMMUNITY STRUCTURE[J]. ENVIRONMENTAL ENGINEERING , 2021, 39(10): 57-63. doi: 10.13205/j.hjgc.202110008
[14]	LI Chung-yan, ZHANG Xi, SHEN Yu-jun, MENG Hai-bo, WEN Hong-da, ZHENG Sheng-wei, ZHOU Hai-bin, CHENG Hong-sheng. EFFECTS OF TURNING STRATEGY ON AEROBIC FERMENTATION PROPERTY OF PIG BIOGAS RESIDUE[J]. ENVIRONMENTAL ENGINEERING , 2021, 39(1): 130-135. doi: 10.13205/j.hjgc.202101020
[15]	XU Chen, ZHAN Jian, HU Jia-jun, WANG Liu-peng, CHEN Yun-hui, XUE Zhen-zhou. RESEARCH PROGRESS ON INFLUENCING FACTORS OF RAINWATER RUNOFF RETENTION AND POLLUTION INTERCEPTION EFFECT OF EXTENSIVE GREEN ROOF[J]. ENVIRONMENTAL ENGINEERING , 2020, 38(9): 76-81. doi: 10.13205/j.hjgc.202009013
[16]	ZHU Wen-bin, GAO Ming, YIN Zi-he, WU Chuan-fu, WANG Qun-hui. RESEARCH PROGRESS ON CAPROIC ACID PRODUCTION FROM ORGANIC WASTE BY ANAEROBIC FERMENTATION[J]. ENVIRONMENTAL ENGINEERING , 2020, 38(1): 128-134. doi: 10.13205/j.hjgc.202001020
[17]	WANG Lei, ZHAN Han-hui, WANG Qing-qing, WU Gang. RESEARCH PROGRESS OF INFLUENCE PARAMETERS AND METHODS FOR RAPIDLY CULTIVATING AEROBIC GRANULAR SLUDGE[J]. ENVIRONMENTAL ENGINEERING , 2020, 38(5): 1-7,29. doi: 10.13205/j.hjgc.202005001
[18]	CHEN Feng, CHEN Dan, HU Yong-you. ANALYSIS ON INFLUENCING FACTORS OF EFFECT OF HIGH TEMPERATURE AEROBIC BIOLOGICAL DRYING PROCESS OF GARBAGE[J]. ENVIRONMENTAL ENGINEERING , 2020, 38(1): 141-145. doi: 10.13205/j.hjgc.202001022
[19]	LIU Wen-jie, WANG Li-ming, SHEN Yu-jun, ZHANG Xi, MENG Hai-bo, FAN Sheng-yuan, ZHANG Da-niu. EFFECTS OF CARBON TO NITROGEN RATIO ON MATURITY AND ODOR EMISSION IN AEROBIC FERMENTATION OF VEGETABLE WASTE[J]. ENVIRONMENTAL ENGINEERING , 2020, 38(6): 233-239. doi: 10.13205/j.hjgc.202006038
[20]	CALCULATION OF CARBON EMISSION REDUCTION OF NEW ENERGY VEHICLES AND ANALYSIS OF ITS INFLUENCING FACTORS[J]. ENVIRONMENTAL ENGINEERING , 2014, 32(12): 148-152. doi: 10.13205/j.hjgc.201412027

Supplements(0)

Cited By

Cited by

Periodical cited type(2)

1.	蒲浩，王雁，郭泽宇，胡干琳，赵旭. 介孔Pt-Fe/Al_2O_3强化类芬顿催化降解罗丹明B性能与机理. 环境科学学报. 2024(07): 83-94 .
2.	杨兴哲，林大峰，李俊伟，景方飞，左梓涵，唐立娜，杨宗政. 零价铁联合微生物修复氯代脂肪烃污染地下水的研究进展. 工业水处理. 2024(11): 42-51 .

Other cited types(0)

Proportional views

Proportional views

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

Get Citation

PDF

XML

Article Metrics

Article views (330) PDF downloads(11)