分子印迹传感器检测全氟和多氟烷基化合物研究进展

李静; 李颖; 荆珂; 张岁岁; 蒋晨雪

doi:10.13205/j.hjgc.202504009

分子印迹传感器检测全氟和多氟烷基化合物研究进展

doi: 10.13205/j.hjgc.202504009

河海大学环境学院,南京 210098

基金项目:

国家自然科学基金项目（52270155）

详细信息

作者简介:
李静（1999-），女，硕士研究生，主要研究方向为水环境污染监测。lj01172023@163.com

通讯作者:
李颖（1978-），女，教授，主要研究方向为水环境污染监测与治理。hj6688@hhu.edu.cn

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出版历程
- 收稿日期: 2023-06-24
- 录用日期: 2023-12-04
- 修回日期: 2023-11-22
- 刊出日期: 2025-04-01

Research progress of molecular imprinting sensors for detecting perfluoro and polyfluoroalkyl compounds

College of Environment, HoHai University, Nanjing 210098, China

摘要

摘要: 针对全氟和多氟烷基化合物（per-and polyfluoroalkyl substances， PFAS）在环境中的普遍存在及潜在危害，分类总结了分子印迹传感器检测PFAS的应用研究进展，并阐述了传感器的检测原理、性能和信号转化机制。传统的色谱法和质谱法检测PFAS价格高昂、操作复杂，需要专业的操作人员，无法满足原位检测和连续监测的需求。已有研究表明分子印迹传感器能够对目标分析物快速响应，可降低PFAS的检测复杂性和检测成本，是一种具有发展前景的测定PFAS的方法。分子印迹传感器虽然在PFAS的检测应用中取得了巨大进展，但其在实际应用中仍面临灵敏度、选择性、便携性和商品化问题等方面的挑战，需进一步完善。开发纳米材料和微电极在分子印迹传感器检测中的应用、研究现场连续监测型传感器以及分子印迹传感器标准化、小型化和智能化是未来的重要发展方向。
- 全氟化合物 /
- 多氟烷基化合物 /
- 分子印迹传感器 /
- 检测
Abstract: In view of the ubiquitous and potential hazards of per- and polyfluoroalkyl substances （PFAS） in the environment， the paper classified and summarized the application research progress of molecular imprinting sensors for detecting PFAS， and explored the detection principle， performance and signal conversion mechanism of the sensors. Traditional chromatography and mass spectrometry are expensive and complicated in detecting PFAS， and require professional operators， cannot meet the requirements of in-situ detection and continuous monitoring. Previous studies have shown that molecular imprinting sensors can respond quickly to the target analyte， reduce the detection complexity and cost of PFAS， and is a promising method for the determination of PFAS. Although the molecularly imprinting sensor has made great progress in application of PFAS detection， it still faces challenges in practical application， such as sensitivity， selectivity， portability and commercialization， which need further improvement. Future study should focus on the application of nano-materials and microelectrodes in the detection of molecularly imprinting sensors， the research of on-site continuous monitoring sensors， as well as the standardization， miniaturization and intelligence of molecular imprinting sensors.
- perfluorinated compounds /
- polyfluoroalkyl compounds /
- molecular imprinting sensor /
- detection

HTML全文

1 典型全氟和多氟烷基化合物的结构式

1. Structure formulas of typical per- and polyfluoroalkyl substances

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2 分子印迹传感器的构建和检测原理

2. Construction and detection principle of molecular imprinting sensors

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1 分子印迹传感器检测PFAS应用分类

1. Application classification of molecular imprinting sensors for detecting PFAS

分子印迹传感器类型	目标分析物	功能单体	样本	检测限	检测范围	参考文献
电化学	PFOS	邻苯二胺	氨缓冲液	20 ng/L	0.1nmol/L~1.5μmol/L	[17]
	PFOA	吡咯	PBS缓冲液	41 μg/L	10 μmol/L~10mmol/L	[18]
	PFOS	邻苯二胺	氨缓冲液	25 ng/L	0.05~500 nmol/L	[19]
	Gen X	邻苯二胺	氨缓冲液	82.5 pg/L	1~5000 pmol/L	[20]
	PFOS	邻苯二胺	PBS缓冲液和河水	1.7 ng/L	0.05~0.5 nmol/L	[21]
	PFOA	吡咯	Na₂SO₄溶液	444 ng/L	10 nmol/L~90 μmol/L	[22]
	PFOS	铬介孔有机金属框架	PBS缓冲液	0.5 ng/L	0.02 nmol/L~20 μmol/L	[23]
光电	PFOS	丙烯酰胺	PBS缓冲液	86 ng/L	0.5~10 μmol/L	[25]
	PFOA	丙烯酰胺	Tris-HCl溶液	10 ng/L	0.48 nmol/L~2.4 μmol/L	[26]
	PFOSF	丙烯酰胺	水溶液	10 ng/L	0.01~995 nmol/L	[27]
电化学发光	PFOA	吡咯	PBS缓冲液	10 ng/L	0.48~966 nmol/L	[40]
荧光	PFOS	3-氨基丙基三乙氧基硅烷	河水	5.57 μg/L	10.36~90.2 nmol/L	[41]
	PFOA	3-氨基丙基三乙氧基硅烷	醋酸缓冲液	10 μg/L	0.25~15 μmol/L	[42]
	PFOS	壳聚糖	水、血清和尿液	0.4，66，85 pg/L	0.04~0.4 pmol/L	[43]
	PFOS	N,O-双(三甲基硅烷基)三氟乙酰胺	水	5 ng/L	0.01~15 nmol/L	[44]
光纤	PFOA	乙烯基苄基三甲基氯化铵和全氟癸基丙烯酸酯	水	0.13 μg/L	2~9 nmol/L	[46]

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