污水处理系统中噬菌体对抗生素抗性基因传播影响的研究进展

林彦含; 包芮齐; 付婧怡; 陈乐怡; 陈红

doi:10.13205/j.hjgc.202509012

污水处理系统中噬菌体对抗生素抗性基因传播影响的研究进展

doi: 10.13205/j.hjgc.202509012

1. 浙江大学环境与资源学院, 杭州 310058

基金项目:

国家自然基金科学项目（W2411031）；浙江省自然科学基金联合基金资助项目（LZJWZ23E090007）

详细信息

作者简介:
林彦含（2000—），女，硕士研究生，主要研究方向为环境微生物。linyanhan@zju.edu.cn

通讯作者:
陈红（1969—），女，教授，主要研究方向为新污染物控制技术、环境微生物耐药及风险。chen_hong@zju.edu.cn

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- 被引次数: 0
出版历程
- 收稿日期: 2025-05-15
- 网络出版日期: 2025-11-05
- 刊出日期: 2025-09-01

Role of bacteriophages in spread of antibiotic resistance genes in wastewater treatment systems： a review

1. College of Environmental and Resource Sciences, Zhejiang University, Hangzhou 310058, China

摘要

摘要: 抗生素耐药性传播已成为全球公共卫生领域的重大挑战。污水处理系统作为抗生素抗性基因（antibiotic resistance genes， ARGs）的重要储存库和传播节点，其微生物生态过程备受关注。噬菌体作为细菌病毒和潜在的基因转移载体，在ARGs传播中发挥着双重作用，其通过裂解作用直接清除耐药菌的同时，可通过转导机制促进ARGs的水平转移。这种矛盾性使得阐明噬菌体调控ARGs传播机制成为环境微生物学研究的核心问题之一。采用文献计量学方法，系统分析了1980—2024年间全球相关研究文献，重点探讨了污水处理系统中噬菌体介导ARGs传播的作用机制，为制定ARGs的精准防控策略提供理论依据。
- 噬菌体 /
- 抗生素抗性基因 /
- 污水处理系统 /
- 水平基因转移 /
- 转导
Abstract: The global spread of antibiotic resistance has emerged as a major public health concern. Wastewater treatment systems are regarded as key reservoirs and dissemination routes for antibiotic resistance genes （ARGs）， and increasing attention has been directed toward the microbial ecological processes within these systems. Bacteriophages， as bacterial viruses and potential mediators of gene transfer， play a dual role in this process. They can eliminate resistant bacteria through lysis while also facilitating the horizontal transfer of ARGs through transduction. This dual functionality presents both opportunities and challenges in the regulation of gene dissemination. In this study， bibliometric analysis was used to systematically examine global research literature from 1980 to 2024， with a focus on the mechanisms by which bacteriophages influence the spread of ARGs in wastewater treatment systems. The findings provide a theoretical foundation for the development of targeted strategies to control the spread of antibiotic resistance.
- bacteriophage /
- antibiotic resistance gene /
- wastewater treatment system /
- horizontal gene transfer /
- transduction

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