ADVANCEMENTS IN PRODUCING MEDIUM CHAIN CARBOXYLIC ACIDS VIA ANAEROBIC DIGESTION

WU Fan; JIANG Hao; LI Ye-qing

doi:10.13205/j.hjgc.202108021

Volume 39 Issue 8

Jan. 2022

Turn off MathJax

Article Contents

Article Navigation > ENVIRONMENTAL ENGINEERING > 2021 > 39(8): 150-155,216

WU Fan, JIANG Hao, LI Ye-qing. ADVANCEMENTS IN PRODUCING MEDIUM CHAIN CARBOXYLIC ACIDS VIA ANAEROBIC DIGESTION[J]. ENVIRONMENTAL ENGINEERING , 2021, 39(8): 150-155,216. doi: 10.13205/j.hjgc.202108021

Citation:

WU Fan, JIANG Hao, LI Ye-qing. ADVANCEMENTS IN PRODUCING MEDIUM CHAIN CARBOXYLIC ACIDS VIA ANAEROBIC DIGESTION[J]. ENVIRONMENTAL ENGINEERING , 2021, 39(8): 150-155,216. doi: 10.13205/j.hjgc.202108021

WU Fan, JIANG Hao, LI Ye-qing. ADVANCEMENTS IN PRODUCING MEDIUM CHAIN CARBOXYLIC ACIDS VIA ANAEROBIC DIGESTION[J]. ENVIRONMENTAL ENGINEERING , 2021, 39(8): 150-155,216. doi: 10.13205/j.hjgc.202108021

Citation:

PDF( 1405 KB)

ADVANCEMENTS IN PRODUCING MEDIUM CHAIN CARBOXYLIC ACIDS VIA ANAEROBIC DIGESTION

doi: 10.13205/j.hjgc.202108021

Beijing Key Laboratory of High Value Utilization of Biogas, College of New Energy and Materials, China University of Petroleum(Beijing), Beijing 102249, China

Received Date: 2020-08-25
Available Online: 2022-01-18

Abstract

Abstract

The utilization of waste resources can help solve many problems including environmental pollution and resource shortage. Due to the wide application and high added value of medium chain carboxylic acids(MCCAs),the chain elongation technology has attracted wide attention in recent years. Chain elongation process could convert various biological wastes into MCCAs by the metabolism of specific microorganisms. Firstly these functional microorganisms were comprehensively introduced. Then, the mechanism (β-reverse oxidation) and reactions of chain elongation were described in details. In recent years, there were several advancements in chain elongation such as bio-electrochemical system, product extraction technology. Then the principles, practical applications and research progresses of those technologies which was beneficial to improving the yield of caproic acid, optimizing the process flow and reducing the operation costs were systematically introduced. Finally, the advantages, challenges and promoting approaches of mentioned methods were summarized.
- medium chain carboxylic acids,
- chain elongation technologies,
- anaerobic digestion,
- metabolic pathways,
- microorganisms

FullText(HTML)

References(46)

References

[1]	WU Q L,BAO X,GUO W Q,et al.Medium chain carboxylic acids production from waste biomass:current advances and perspectives[J].Biotechnology Advances,2019,37(5):599-615.
[2]	MARSHALL C W,LABELLE E V,MAY H D.Production of fuels and chemicals from waste by microbiomes[J].Curr Opin Biotechnol,2013,24(3):391-397.
[3]	AGLER M T,WRENN B A,ZINDER S H,et al.Waste to bioproduct conversion with undefined mixed cultures:the carboxylate platform[J].Trends in Biotechnology,2011,29(2):70-78.
[4]	王薪淯,朱晓宇,李海翔,等.乳酸碳链延长技术及其在有机废弃物资源化中的应用研究进展[J].应用与环境生物学报,2020,26(4):827-835.
[5]	CANDRY P,ULCAR B,PETROGNANI C,et al.Ethanol:propionate ratio drives product selectivity in odd-chain elongation with Clostridium kluyveri and mixed communities[J].Bioresource Technology,2020,313:123651.
[6]	KENEALY WR,CAO Y,WEIMER P J.Production of caproic acid by cocultures of ruminal cellulolytic bacteria and Clostridium kluyveri grown on cellulose and ethanol[J].Applied microbiology and biotechnology,1995,44(3/4):507-513.
[7]	BARKER H,KAMEN M,BORNSTEIN B.The synthesis of butyric and caproic acids from ethanol and acetic acid by Clostridium kluyveri [J].Proceedings of the National Academy of Sciences of the United States of America,1945,31(12):373.
[8]	ANGENENT LT,RICHTER H,BUCKEL W,et al.Chain elongation with reactor microbiomes:open-culture biotechnology to produce biochemicals[J].Environmental Science & Technology,2016,50(6):2796-2810.
[9]	BARKER H,TAHA S.CLOSTRIDIUM kluyverii,an organism concerned in the formation of caproic acid from ethyl alcohol[J].Journal of Bacteriology,1942,43(3):347.
[10]	COMA M,VILCHEZ-VARGAS R,ROUME H,et al.Product diversity linked to substrate usage in chain elongation by mixed-culture fermentation[J].Environmental Science & Technology,2016,50(12):6467-6476.
[11]	ROGHAIR M,STRIK DPBTB,STEINBUSCH KJJ,et al.Granular sludge formation and characterization in a chain elongation process[J].Process Biochemistry,2016,51(10):1594-1598.
[12]	KIM B C,JEON B S,KIM S,t al.Caproiciproducens galactitolivorans gen.nov.,sp.nov.,a bacterium capable of producing caproic acid from galactitol,isolated from a wastewater treatment plant[J].International Journal of Systematic and Evolutionary Microbiology,2015,65(12):4902-4908.
[13]	ZHU X,ZHOU Y,WANG Y,et al.Production of high-concentration n-caproic acid from lactate through fermentation using a newly isolated Ruminococcaceae bacterium CPB6[J].Biotechnology for Biofuels,2017,10(1):102.
[14]	AGLER M T,SPIRITO C M,USACK J G.Chain elongation with reactor microbiomes:upgrading dilute ethanol to medium-chain carboxylates[J].Energy & Environmental Science,2012,5(8):8189-8192.
[15]	TAO Y,ZHU X Y,WANG H,et al.Complete genome sequence of Ruminococcaceae bacterium CPB6:a newly isolated culture for efficient n-caproic acid production from lactate[J].Journal of Biotechnology,2017,259:91-94.
[16]	NELSON R,PETERSON D,KARP E,et al.Mixed carboxylic acid production by megasphaera elsdenii from glucose and lignocellulosic hydrolysate[J].Fermentation,2017,3(1):10.
[17]	CHOI K,JEON B S,KIM B C,et al.In situ biphasic extractive fermentation for hexanoic acid production from sucrose by Megasphaera elsdenii NCIMB 702410[J].Applied Biochemistry and Biotechnology,2013,171(5):1094-1107.
[18]	TARASOV A,BORZENKOV I,BELYAYEV S.Investigation of the trophic relations between anaerobic microorganisms from an underground gas repository during methanol utilization[J].Microbiology,2011,80(2):180-187.
[19]	WALLACE R,MCKAIN N,MCEWAN N,et al.Eubacterium pyruvativorans sp.nov.,a novel non-saccharolytic anaerobe from the rumen that ferments pyruvate and amino acids,forms caproate and utilizes acetate and propionate[J].International Journal of Systematic and Evolutionary Microbiology,2003,53(4):965-970.
[20]	BARKER H A,TAHA S M.Clostridium kluyverii,an organism concerned in the formation of caproic acid from ethyl alcohol[J].Journal of Bacteriology 1942,43(3):347-363.
[21]	JEON B S,KIM B C,UM Y,et al.Production of hexanoic acid from D-galactitol by a newly isolated Clostridium sp.BS-1[J].Applied Microbiology and Biotechnology,2010,88(5):1161-1167.
[22]	LANJEKAR V B,MARATHE N P,RAMANA V V,et al.Megasphaera indica sp.nov.,an obligate anaerobic bacteria isolated from human faeces[J].International Journal of Systermatic and Evolutionary Microbiology,2014,64(Pt 7):2250-2256.
[23]	JEON B S,KIM S,SANG B I.Megasphaera hexanoica sp.nov.,a medium-chain carboxylic acid-producing bacterium isolated from a cow rumen[J].International Journal Systermatic and Evolutionary Microbiology,2017,67(7):2114-2120.
[24]	GE S,USACK J G,SPIRITO C M,et al.Long-term n-caproic acid production from yeast-fermentation beer in an anaerobic bioreactor with continuous product extraction[J].Environmental Science & Technology,2015,49(13):8012-8021.
[25]	SCARBOROUGH M,LAWSON C,HAMILTON J,et al.Metatranscriptomic and thermodynamic insights into medium-chain fatty acid production using an anaerobic icrobiome[J].Nasysterns,2018,3(6).
[26]	ANDERSEN S J,CANDRY P,BASADRE T,et al.Electrolytic extraction drives volatile fatty acid chain elongation through lactic acid and replaces chemical pH control in thin stillage fermentation[J].Biotechnology for Biofuels,2015,8(1):221.
[27]	ROGHAIR M,HOOGSTAD T,STRIK DPBTB,et al.Controlling ethanol use in chain elongation by CO₂ loading rate[J].Environmental Science & Technology,2018,52(3):1496-1505.
[28]	LIU Y H,HE P J,SHAO L M,et al.Significant enhancement by biochar of caproate production via chain elongation[J].Water Research,2017,119:150-159.
[29]	XU J J,HAO J X,GUZMAN J J L,et al.Temperature-phased conversion of acid whey waste into medium-chain carboxylic acids via lactic acid:no external e-donor[J].Joule,2018,3(2):885-888.
[30]	DESBOIS A P,SMITH V J.Antibacterial free fatty acids:activities,mechanisms of action and biotechnological potential[J].Applied Microbiology and Biotechnology,2010,85(6):1629-1642.
[31]	SPIRITO C M,RICHTER H,RABAEY K,et al.Chain elongation in anaerobic reactor microbiomes to recover resources from waste[J].Current Opinion in Biotechnology,2014,27:115-122.
[32]	STEINBUSCH K J,HAMELERS H V,PLUGGE C M,et al.Biological formation of caproate and caprylate from acetate:fuel and chemical production from low grade biomass[J].Energy & Environmental Science,2011,4(1):216-224.
[33]	DE ARAÚJO CAVALCANTE W,LEITÃO R C,GEHRING T A,et al.Anaerobic fermentation for n-caproic acid production:a review[J].Process Biochemistry,2017,54:106-119.
[34]	ZHU X Y,TAO Y,LIANG C,et al.The synthesis of n -caproate from lactate:a new efficient process for medium-chain carboxylates production[J].Scientific Reports,2015,5:14360.
[35]	CAVALCANTE W D A,LEITÃO R C,GEHRING T A,et al.Anaerobic fermentation for n-caproic acid production:a review[J].Process Biochemistry,2017,54:106-119.
[36]	JADHAV D A,RAY S G,GHANGREKAR M M.Third generation in bio-electrochemical system research:a systematic review on mechanisms for recovery of valuable by-products from wastewater[J].Renewable and Sustainable Energy Reviews,2017,76:1022-1031.
[37]	VAN EERTEN-JANSEN M C,TER HEIJNE A,GROOTSCHOLTEN T I,et al.Bioelectrochemical production of caproate and caprylate from acetate by mixed cultures[J].ACS Sustainable Chemistry & Engineering,2013,1(5):513-518.
[38]	RAES S M,JOURDIN L,BUISMAN C J,et al.Continuous long-term bioelectrochemical chain elongation to butyrate[J].Chem ElectroChem,2017,4(2):386-395.
[39]	JABEEN G,FAROOQ R.Bio-electrochemical synthesis of commodity chemicals by autotrophic acetogens utilizing CO₂ for environmental remediation[J].Journal of Biosciences,2016,41(3):367-380.
[40]	JOURDIN L,RAES S M T,BUISMAN C J N,et al.Critical biofilm growth throughout unmodified carbon felts allows continuous bioelectrochemical chain elongation from CO₂ up to caproate at high current density[J].Frontiers in Energy Research,2018,6(7).
[41]	REDDY M V,ELMEKAWY A,PANT D.Bioelectrochemical synthesis of caproate through chain elongation as a complementary technology to anaerobic digestion[J].Biofuels,Bioproducts and Biorefining,2018,12(6):966-977.
[42]	WANG Y D,LI Y X,LI Y,et al.Extraction equilibria of monocarboxylic acids with trialkylphosphine oxide[J].Journal of Chemical & Engineering Data,2001,46(4):831-837.
[43]	WASEWAR K L,SHENDE D Z.Extraction of caproic acid using tri-n-butyl phosphate in benzene and toluene at 301 K[J].Journal of Chemical & Engineering Data,2010,55(9):4121-4125.
[44]	JEON B S,MOON C,KIM B C,et al.In situ extractive fermentation for the production of hexanoic acid from galactitol by Clostridium sp.BS-1[J].Enzyme and Microbial Technology,2013,53(3):143-151.
[45]	KUCEK L A,NGUYEN M,ANGENENT L T.Conversion of l-lactate into n-caproate by a continuously fed reactor microbiome[J].Water Research,2016,93:163-171.
[46]	XU J,GUZMAN J J,ANDERSEN S J,et al.In-line and selective phase separation of medium-chain carboxylic acids using membrane electrolysis[J].Chemical Communications,2015,51(31):6847-6850.