PRELIMINARY STUDY ON WATER QUALITY CRITERIA AND ECOLOGICAL RISK ASSESSMENT OF CARBAMAZEPINE IN FRESHWATER IN CHINA

CHAO Zhu; XIA Peng; SI Jingyi; JIN Qi; BAI Yingchen; TAN Weiqiang

doi:10.13205/j.hjgc.202304024

Volume 41 Issue 4

Apr. 2023

Turn off MathJax

Article Contents

Article Navigation > ENVIRONMENTAL ENGINEERING > 2023 > 41(4): 170-177

CHAO Zhu, XIA Peng, SI Jingyi, JIN Qi, BAI Yingchen, TAN Weiqiang. PRELIMINARY STUDY ON WATER QUALITY CRITERIA AND ECOLOGICAL RISK ASSESSMENT OF CARBAMAZEPINE IN FRESHWATER IN CHINA[J]. ENVIRONMENTAL ENGINEERING , 2023, 41(4): 170-177. doi: 10.13205/j.hjgc.202304024

Citation:

CHAO Zhu, XIA Peng, SI Jingyi, JIN Qi, BAI Yingchen, TAN Weiqiang. PRELIMINARY STUDY ON WATER QUALITY CRITERIA AND ECOLOGICAL RISK ASSESSMENT OF CARBAMAZEPINE IN FRESHWATER IN CHINA[J]. ENVIRONMENTAL ENGINEERING , 2023, 41(4): 170-177. doi: 10.13205/j.hjgc.202304024

Citation:

CHAO Zhu, XIA Peng, SI Jingyi, JIN Qi, BAI Yingchen, TAN Weiqiang. PRELIMINARY STUDY ON WATER QUALITY CRITERIA AND ECOLOGICAL RISK ASSESSMENT OF CARBAMAZEPINE IN FRESHWATER IN CHINA[J]. ENVIRONMENTAL ENGINEERING , 2023, 41(4): 170-177. doi: 10.13205/j.hjgc.202304024

PDF( 6854 KB)

PRELIMINARY STUDY ON WATER QUALITY CRITERIA AND ECOLOGICAL RISK ASSESSMENT OF CARBAMAZEPINE IN FRESHWATER IN CHINA

doi: 10.13205/j.hjgc.202304024

CHAO Zhu^1,2,
XIA Peng²,
SI Jingyi²,
JIN Qi²,
BAI Yingchen^{1,2
,},
TAN Weiqiang^1
,

1. School of Environment and Municipal Engineering, Qingdao University of Technology, Qingdao 266033, China;
2. State Key Laboratory of Environmental Criteria and Risk Assessment, Chinese Research Academy of Environmental Sciences, Beijing 100012, China

Received Date: 2022-07-16
Available Online: 2023-05-26
Publish Date: 2023-04-01

Abstract

Abstract

Carbamazepine is an important micro-pollutant with high usage and detection rate in natural water. Based on the acute and chronic toxicity data of carbamazepine to freshwater organisms in China, the water quality criteria were derived for protecting freshwater organisms in China. Based on the exposure concentration data of carbamazepine in surface water in China, the ecological risk of carbamazepine in freshwater environment was assessed. The results showed that: 1) The acute toxicity data of oxytetracycline involved 10 species of 8 families in 5 phyla, and the most sensitive species was Hydra vulgaris; the chronic data involved 18 species of 10 families in 4 phyla, and the most sensitive species was Lymnaea stagnalis; 2) The short-term and the long-term water quality criteria of carbamazepine derived by the toxicity percentage ranking method were 2.17 mg/L and 0.0034 mg/L, respectively; the short-term and the long-term water quality criteria of carbamazepine derived by the species sensitivity distribution method were 7.49 mg/L and 0.004 mg/L, respectively. According to the comprehensive evaluation, the species sensitivity distribution method was superior to the toxicity percentage ranking method; 3) A total of 338 carbamazepine concentration data in major water bodies in year 2010 to 2022 were collected, and the ecological risk of carbamazepine was evaluated by use of the probability assessment method, and it was found that the carbamazepine in surface water posed little risk to aquatic organisms. Therefore, this study will provide data support and scientific guidance for the environmental management of carbamazepine in China.
- carbamazepine,
- freshwater quality criteria,
- ecological risk,
- species sensitivity distribution method,
- toxicity percentage ranking method

FullText(HTML)

References(59)

References

[1]	BATUCAN N S P, TREMBLAY L A, NORTHCOTT G L, et al. Medicating the environment: a critical review on the risks of carbamazepine, diclofenac and ibuprofen to aquatic organisms[J]. Environmental Advances, 2022, 7(6): 100-114.
[2]	FENG J L, LIU Q, RU X L, et al. Occurrence and distribution of priority pharmaceuticals in the Yellow River and the Huai River in Henan, China[J]. Environmental Science and Pollution Research, 2020, 27(14): 16816-16826.
[3]	MHEIDLI N, MALLI A, MANSOUR F, et al. Occurrence and risk assessment of pharmaceuticals in surface waters of the Middle East and North Africa: a review[J]. Science of the Total Environment, 2022, 851(Pt.2): 158-176.
[4]	ZIND H, MONDAMERT L, REMAURY Q B, et al. Occurrence of carbamazepine, diclofenac, and their related metabolites and transformation products in a French aquatic environment and preliminary risk assessment[J]. Water Research, 2021, 196(6): 17-32.
[5]	PALMA P, FIALHO S, LIMA A, et al. Pharmaceuticals in a Mediterranean Basin: the influence of temporal and hydrological patterns in environmental risk assessment[J]. Science of the Total Environment, 2020, 9(10): 196-205.
[6]	LIU N, JIN X W, FENG C L, et al. Ecological risk assessment of fifty pharmaceuticals and personal care products (PPCPs) in Chinese surface waters: a proposed multiple-level system[J]. Environment International, 2020, 13(6): 105-124.
[7]	司静宜, 洪亚军, 夏鹏, 等. 我国土霉素的淡水生物水质基准标准及生态风险评估研究[J]. 环境科学研究,2022, 36(2): 403-413.
[8]	夏鹏, 巢铸, 司静宜, 等. 中国铊的淡水水生生物水质基准研究初探[J]. 环境科学与技术,2021, 44(10): 19-26.
[9]	苏海磊, 郭飞, 魏源, 等. 中国保护水生生物的甲基汞水质标准制订初探[J]. 环境工程技术学报,2020, 10(3): 512-516.
[10]	闫振飞, 陈季康, 赵鑫, 等. 甲基叔丁基醚的水质基准阈值和生态风险评估[J]. 环境工程,2019, 37(6): 170-176.
[11]	Australian and New Zealand Environment and Conservation Council. Pathway for Toxicant Default Guideline Value Publication [R]. Australia: Anzecc and Armcanz, 2021.
[12]	Canadian Council of Ministers of the Environment (CCME). Scientific Criteria Document for the Development of the Canadian Water Quality Guideline for Carbamazepine[R]. Manitoba: Canadian Council of Ministers of the Environment,2018.
[13]	翁郁馨, 杨慧婷, 陈辉辉, 等. 江苏高宝邵伯湖表层水体典型精神类药物及其代谢产物的污染水平、分布特征及风险评估[J]. 湖泊科学,2022,34(6): 1993-2004.
[14]	生态环境部. 淡水水生生物水质基准制定技术指南:HJ 831—2022[S].北京:中国标准出版社, 2022.
[15]	United States Environmental Protection Agency (US EPA). Guidelines for Deriving Numerical National Aquatic Life Criteria for Protection of Aquatic Organisms and Their Uses [R]. Washington DC: Office of Water, 1985.
[16]	SUN F H, TAO Y R, SHI D, et al. Ecological risk assessment of phthalate esters (DBP and DEHP) in surface water of China[J]. Frontiers in Environmental Science, 2021, 9(3): 284-294.
[17]	FERRARI B T, PAXEUS N, GIUDICE R L, et al. Ecotoxicological impact of pharmaceuticals found in treated wastewaters: study of carbamazepine, clofibric acid, and diclofenac[J]. Ecotoxicology and Environmental Safety, 2003, 55(3): 359-370.
[18]	JOS A, REPETTO G, RIOS J C, et al. Ecotoxicological evaluation of carbamazepine using six different model systems with eighteen endpoints[J]. Toxicology in Vitro, 2003, 17(5): 525-532.
[19]	张风兆. 卡马西平对小球藻、大型溞、斑马鱼的毒性效应[D]. 泰安:山东农业大学, 2016.
[20]	KIM Y, CHOI K, JUNG J, et al. Aquatic toxicity of acetaminophen, carbamazepine, cimetidine, diltiazem and six major sulfonamides, and their potential ecological risks in Korea[J]. Environment International, 2007, 33(3): 370-375.
[21]	HAN G H, HUR H G, KIM S D. Ecotoxicological risk of pharmaceuticals from wastewater treatment plants in Korea: occurrence and toxicity to Daphnia magna[J]. Environmental Toxicology and Chemistry, 2006, 25(1): 265-271.
[22]	LI M H. Acute toxicity of 30 pharmaceutically active compounds to freshwater planarians, Dugesia japonica[J]. Toxicological and Environmental Chemistry, 2013, 95: 1157-1170.
[23]	QUINN B, GAGNE F, BLAISE C. An investigation into the acute and chronic toxicity of eleven pharmaceuticals (and their solvents) found in wastewater effluent on the cnidarian, Hydra attenuata[J]. Science of the Total Environment, 2008, 389(2): 306-314.
[24]	WEIGT S, HUEBLER N, STRECKER R, et al. Zebrafish (Danio rerio) embryos as a model for testing proteratogens[J]. Toxicology, 2011, 281(1): 25-36.
[25]	BRANDHOF E J, MONTFORTS M. Fish embryo toxicity of carbamazepine, diclofenac and metoprolol[J]. Ecotoxicology and Environmental Safety, 2010, 73(8): 1862-1866.
[26]	LI Z H, ZLABEK V, VELISEK J, et al. Acute toxicity of carbamazepine to juvenile rainbow trout (Oncorhynchus mykiss): effects on antioxidant responses, hematological parameters and hepatic EROD[J]. Ecotoxicology and Environmental Safety, 2011, 74(3): 319-327.
[27]	KIM J W, ISHIBASHI H, YAMAUCHI R, et al. Acute toxicity of pharmaceutical and personal care products on freshwater crustacean (Thamnocephalus platyurus) and fish (Oryzias latipes)[J]. The Journal of Toxicological Sciences, 2009, 34(2): 227-232.
[28]	LAVILLE N, ATASSA S, GOMEZ E, et al. Effects of human pharmaceuticals on cytotoxicity, EROD activity and ROS production in fish hepatocytes[J]. Toxicology, 2004, 196(1): 41-55.
[29]	MALARVIZHI A, KAVITHA C, SARAVANAN M, et al. Carbamazepine (CBZ) induced enzymatic stress in gill, liver and muscle of a common carp, Cyprinus carpio[J]. Journal of King Saud University-Science, 2012, 24(2): 179-186.
[30]	MELVIN S D, CAMERON M C, LANCTOT C M. Individual and mixture toxicity of pharmaceuticals naproxen, carbamazepine, and sulfamethoxazole to australian striped marsh frog tadpoles (Limnodynastes peronii)[J]. Journal of Toxicology and Environmental Health, Part A, 2014, 77(6): 337-345.
[31]	OETKEN M, NENTWIG G, LOFFLER D, et al. Effects of pharmaceuticals on aquatic invertebrates. Part Ⅰ. the antiepileptic drug carbamazepine[J]. Archives of Environmental Contamination and Toxicology, 2005, 49(3): 353-361.
[32]	LURLING M, SARGANTE, ROESSINK I. Life-history consequences for Daphnia pulex exposed to pharmaceutical carbamazepine[J]. Environmental Toxicology, 2006, 21(2): 172-180.
[33]	DIETRICH S, PLOESSL F, BRACHER F, et al. Single and combined toxicity of pharmaceuticals at environmentally relevant concentrations in Daphnia magna: a multigenerational study[J]. Chemosphere, 2010, 79(1): 60-66.
[34]	TRIEBSKORN R, CASPER H, SCHEIL V, et al. Ultrastructural effects of pharmaceuticals (carbamazepine, clofibric acid, metoprolol, diclofenac) in rainbow trout (Oncorhynchus mykiss) and common carp (Cyprinus carpio)[J]. Analytical and Bioanalytical Chemistry, 2007, 387(4): 1405-1416.
[35]	MADUREIRA T V, ROCHAM J, CRUZEIRO C, et al. The toxicity potential of pharmaceuticals found in the Douro River estuary (Portugal): evaluation of impacts on fish liver, by histopathology, stereology, vitellogenin and CYP1A immunohistochemistry, after sub-acute exposures of the zebrafish model[J]. Environmental Toxicology and Pharmacology, 2012, 34(1): 34-45.
[36]	LI Z H, ZLABEK V, GRABIC R, et al. Enzymatic alterations and RNA/DNA ratio in intestine of rainbow trout, Oncorhynchus mykiss, induced by chronic exposure to carbamazepine[J]. Ecotoxicology, 2010, 19(5): 872-878.
[37]	LI Z H, VELISEK J, ZLABEK V, et al. Hepatic antioxidant status and hematological parameters in rainbow trout, Oncorhynchus mykiss, after chronic exposure to carbamazepine[J]. Chemico-Biological Interactions, 2010, 183(1): 98-104.
[38]	LI Z H, ZLABEK V, VELISEK J, et al. Physiological condition status and muscle-based biomarkers in rainbow trout (Oncorhynchus mykiss), after long-term exposure to carbamazepine[J]. Journal of Applied Toxicology, 2010, 30(3): 197-203.
[39]	OVERTURF M D, OVERTURF C L, BAXTER D, et al. Early life-stage toxicity of eight pharmaceuticals to the fathead minnow, Pimephales promelas[J]. Archives of Environmental Contamination and Toxicology, 2012, 62(3): 455-464.
[40]	THOMAS M A, JOSHI P, KLAPER R D. Gene-class analysis of expression patterns induced by psychoactive pharmaceutical exposure in fathead minnow (Pimephales promelas) indicates induction of neuronal systems[J]. Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 2012, 155(1): 109-120.
[41]	JARVIS A L, BERNOT M J, BERNOT R J. The effects of the psychiatric drug carbamazepine on freshwater invertebrate communities and ecosystem dynamics[J]. Science of the Total Environment, 2014, 496: 461-470.
[42]	BRAIN R A, JOHNSON D J, RICHARDS S M, et al. Microcosm evaluation of the effects of an eight pharmaceutical mixture to the aquatic macrophytes Lemna gibba and Myriophyllum sibiricum[J]. Aquatic Toxicology, 2004, 70(1): 23-40.
[43]	CLEUVERS M. Aquatic ecotoxicity of pharmaceuticals including the assessment of combination effects[J]. Toxicology Letters, 2003, 142(3): 185-194.
[44]	ZHANG W, ZHANG M, LIN K, et al. Eco-toxicological effect of Carbamazepine on Scenedesmus obliquus and Chlorella pyrenoidosa[J]. Environmental Toxicology and Pharmacology, 2012, 33(2): 344-352.
[45]	阎晓静, 王金花, 朱鲁生, 等. 卡马西平对小球藻生长的影响和氧化损伤[J].农业环境科学学报. 2017, 36(4): 643-650.
[46]	VERNOUILLET G, EULLAFFROY P, LAJEUNESSE A, et al. Toxic effects and bioaccumulation of carbamazepine evaluated by biomarkers measured in organisms of different trophic levels[J]. Chemosphere, 2010, 80(9): 1062-1068.
[47]	SUN J, LUO Q, WANG D H, et al. Occurrences of pharmaceuticals in drinking water sources of major river watersheds, China[J]. Ecotoxicology and Environmental Safety, 2015, 117(8): 132-140.
[48]	WU M H, XIANG J J, QUE C J, et al. Occurrence and fate of psychiatric pharmaceuticals in the urban water system of Shanghai, China[J]. Chemosphere, 2015, 138(6): 486-493.
[49]	MA R X, WANG B, LU S X, et al. Characterization of pharmaceutically active compounds in Dongting Lake, China: occurrence, chiral profiling and environmental risk[J]. Science of the Total Environment, 2016, 557(2): 268-275.
[50]	WU C X, HUANG X L, WITTER J D, et al. Occurrence of pharmaceuticals and personal care products and associated environmental risks in the central and lower Yangtze river, China[J]. Ecotoxicology and Environmental Safety, 2014, 106(9): 19-26.
[51]	LIU J C, LU G H, XIE Z X, et al. Occurrence, bioaccumulation and risk assessment of lipophilic pharmaceutically active compounds in the downstream rivers of sewage treatment plants[J]. Science of the Total Environment, 2015, 511(3): 54-62.
[52]	纪建飞, 孙佳, 杜尔登, 等. 11种典型PPCPs在污水处理厂尾水及其周围水体中的分布特征与生态风险评估[J].安全与环境工程, 2017, 24(6): 56-61.
[53]	ZHOU H D, WU C Y, HUANG X, et al. Occurrence of selected pharmaceuticals and caffeine in sewage treatment plants and receiving Rivers in Beijing, China[J]. Water Environment Research, 2010, 82(11): 2239-2248.
[54]	DAI G H, WANG B, HUANG J, et al. Occurrence and source apportionment of pharmaceuticals and personal care products in the Beiyun River of Beijing, China[J]. Chemosphere, 2015, 119(7): 1033-1039.
[55]	王龙, 朱丹, 曹云霄, 等. 北京市污水处理厂出水中药物和个人护理品的季节变化及其生态风险评价[J].环境科学学报. 2021, 41(7): 2922-2932.
[56]	ZHU S C, CHEN H, LI J N. Sources, distribution and potential risks of pharmaceuticals and personal care products in Qingshan Lake basin, Eastern China[J]. Ecotoxicology and Environmental Safety, 2013, 96(4): 154-159.
[57]	ZHOU X F, DAI C M, ZHANG Y L, et al. A preliminary study on the occurrence and behavior of carbamazepine (CBZ) in aquatic environment of Yangtze River Delta, China[J]. Environmental Monitoring and Assessment, 2011, 173(1): 45-53.
[58]	WANG Y W, LI Y, HU A Y, et al. Monitoring, mass balance and fate of pharmaceuticals and personal care products in seven wastewater treatment plants in Xiamen City, China[J]. Journal of Hazardous Materials, 2018, 354(9): 81-90.
[59]	ZHAO J L, YING G, LIU Y S, et al. Occurrence and a screening-level risk assessment of human pharmaceuticals in the Pearl River system, South China[J]. Environmental Toxicology and Chemistry, 2010, 29(6): 1377-1384.