Source Jouranl of CSCD
Source Journal of Chinese Scientific and Technical Papers
Included as T2 Level in the High-Quality Science and Technology Journals in the Field of Environmental Science
Core Journal of RCCSE
Included in the CAS Content Collection
Included in the JST China
Indexed in World Journal Clout Index (WJCI) Report
Volume 42 Issue 3
Mar.  2024
Turn off MathJax
Article Contents
WANG Na, YANG Xinyue, CAI Wentao, SUN Jiajing, MA Xiaoyan, ZHANG Yujiao. RELATIONSHIP BETWEEN PARAMETER σ2(k·ECx) AND INTERACTION OF MULTI-COMPONENT MIXTURES[J]. ENVIRONMENTAL ENGINEERING , 2024, 42(3): 58-66. doi: 10.13205/j.hjgc.202403007
Citation: WANG Na, YANG Xinyue, CAI Wentao, SUN Jiajing, MA Xiaoyan, ZHANG Yujiao. RELATIONSHIP BETWEEN PARAMETER σ2(k·ECx) AND INTERACTION OF MULTI-COMPONENT MIXTURES[J]. ENVIRONMENTAL ENGINEERING , 2024, 42(3): 58-66. doi: 10.13205/j.hjgc.202403007

RELATIONSHIP BETWEEN PARAMETER σ2(k·ECx) AND INTERACTION OF MULTI-COMPONENT MIXTURES

doi: 10.13205/j.hjgc.202403007
  • Received Date: 2023-04-11
    Available Online: 2024-05-31
  • Previous studies have found that the parameter k·ECx can characterize the shape of the concentration-reaction curves (CRCs), and its derived parameter σ2(k·ECx) (the variance of k·ECx for each component) can predict the combined toxicity of multi-component mixtures. This study further explored the relationship between σ2(k·ECx) and the strength and mode of joint action. Eleven environmental pollutants were divided into group D (different system) and group S (similar system) according to the value of parameter k·ECx. A total of 18 mixtures (11 in group D, and 7 in group S) were designed. The joint action of mixtures was evaluated by independent action model (IA) and effect residual ratio (ERRx) model. The mixed systems with different parameters k·ECx (group D in this paper) were prone to change the mode of joint action. The mixed systems with similar k·ECx of each component (group S in this paper) kept the mode of interaction unchanged. In the group D, the mode of interaction of mixtures with a larger σ2(k·ECx) was not easy to change. The strength of the joint action of group D was greater than that of group S overall. The strength of the interaction in every mixed system was positively correlated with the σ2(k·ECx). This study revealed the relationship between the σ2(k·ECx) and the joint action of multiple mixtures, and achieved the prejudgement of the joint action of multiple mixtures from a geometric perspective, which can provide certain theoretical support for the environmental risk assessment.
  • loading
  • [1]
    MAAZOUZI C, COUREAU C, PISCART C, et al. Individual and joint toxicity of the herbicide s-metolachlor and a metabolite, deethylatrazine on aquatic crustaceans:difference between ecological groups[J]. Chemosphere, 2016, 165(2):118-125.
    [2]
    WANG Y H, WU S G, CHEN J, et al. Single and joint toxicity assessment of four currently used pesticides to zebrafish (danio rerio) using traditional and molecular endpoints[J]. Chemosphere, 2018, 192:14-23.
    [3]
    WANG D, WANG S, BAI L M, et al. Mathematical modeling approaches for assessing the joint toxicity of chemical mixtures based on luminescent bacteria:a systematic review[J]. Frontiers in Microbiology, 2020, 11:1651-1675.
    [4]
    LIU C N, LI G T, MO L Y, et al. Alteration in concentration-response curves of four n-alkylpyridinium chloride by exposure concentration, time and in their mixtures by uniform design[J]. Science of the Total Environment, 2020, 712:136493.
    [5]
    CHENG F, LI H Z, BROOKS B W, et al. Retrospective risk assessment of chemical mixtures in the big data era:an alternative classification strategy to integrate chemical and toxicological data[J]. Environmental Science And Technology, 2020, 54(10):5925-5927.
    [6]
    LOEWE S. Die mischarznei. Versuch einer allgemeinen pharmakologie der arzneikombinationen[J]. Klin Wochenschr, 1927, (23):1077-1085.
    [7]
    BLISS C I. The toxicity of poisons applied jointly[J]. Annals of Applied Biology, 1939, 3:585-615.
    [8]
    MO L Y, LIU J, QIN L T, et al. Two-stage prediction on effects of mixtures containing phenolic compounds and heavy metals on Vibrio qinghaiensis sp. Q67[J]. Bulletin of Environmental Contamination Toxicology, 2017, 99(1):17-20.
    [9]
    WANG N, WANG X C, MA X Y. Characteristics of concentration-inhibition curves of individual chemicals and applicability of the concentration addition model for mixture toxicity prediction[J]. Ecotoxicology Environmental Safety, 2015, 113:176-182.
    [10]
    CEDERGREEN N, CHRISTENSEN A M, KAMPER A, et al. A review of independent action compared to concentration addition as reference models for mixtures of compounds with different molecular target sites[J]. Environmental Toxicology and Chemistry, 2008, 27:1621-1632.
    [11]
    WANG Z, WANG S, PEIJNENBURG W J G M. Prediction of joint algal toxicity of nano-ceo2/nano-tio2 and florfenicol:independent action surpasses concentration addition[J]. Chemosphere, 2016, 156:8-13.
    [12]
    WANG N, SUN R R, MA X Y, et al. Prediction of the joint action of binary mixtures based on characteristic parameter k·ecx from concentration-response curves[J]. Ecotoxicology and Environmental Safety, 2021, 215(6):112-155.
    [13]
    ZHANG J, LIU S S, ZHANG J, et al. Two novel indices for quantitatively characterizing the toxicity interaction between ionic liquid and carbamate pesticides[J]. Journal of Hazardous Materials, 2012, 240(15):102-109.
    [14]
    WANG L J, LIU S S, ZHANG J, et al. A new effect residual ratio (ERR) method for the validation of the concentration addition and independent action models[J]. Environmental Science and Pollution Research, 2009, 17(5):1080-1089.
    [15]
    WANG N, ZHANG J K, MA X Y, et al. Study of the joint action of multi-component mixtures based on parameter σ2 (k·ECx) characterizing the shape difference of concentration-response curves[J]. Environmental Pollution, 2022, 293:118-486.
    [16]
    DRZYMAŁA J, KALKA J. Elimination of the hormesis phenomenon by the use of synthetic sea water in a toxicity test towards Aliivibrio fischeri[J]. Chemosphere, 2020, 248:126-129.
    [17]
    ZHANG Y H, LIU S S, LIU H L, et al. Evaluation of the combined toxicity of 15 pesticides by uniform design[J]. Pest Management Science, 2010, 66(8):879-887.
    [18]
    ZHU X W, LIU S S, QIN L T, et al. Modeling non-monotonic dose-response relationships:model evaluation and hormetic quantities exploration[J]. Ecotoxicology and Environmental Safety, 2013, 89:130-136.
    [19]
    WANG N, SUN R R, MA X Y, et al. Prediction of the joint action of binary mixtures based on characteristic parameter kec from concentration-response curves[J]. Ecotoxicology Environmental Safety, 2021, 215(6):112-155.
    [20]
    张欢乐, 王娜, 马晓妍,等. 基于特性参数k·ECx和均分射线法的二元混合物联合毒性研究[J]. 生态毒理学报, 2023, 18(1):11-15.
    [21]
    YU Z Y, MO L Y, ZHANG J, et al. Time- and anion-dependent stimulation on triphosphopyridine nucleotide followed by antioxidant responses in Vibrio fischeri after exposure to 1-ethyl-3-methylimidazolium salts[J]. Chemosphere:Environmental Toxicology and Risk Assessment, 2016, 21:112-125.
    [22]
    HODYNA D, BARDEAU J F, METELYTSIA L, et al. Efficient antimicrobial activity and reduced toxicity of 1-dodecyl-3-methylimidazolium tetrafluoroborate ionic liquid/β-cyclodextrin complex[J]. Chemical Engineering Journal, 2016, 284(15):1136-1145.
    [23]
    ZHANG C, SHAO Y T, ZHU L S, et al. Acute toxicity, biochemical toxicity and genotoxicity caused by 1-butyl-3-methylimidazolium chloride and 1-butyl-3-methylimidazolium tetrafluoroborate in zebrafish (danio rerio) livers[J]. Environmental Toxicology and Pharmacology, 2017, 27(24):7-14.
    [24]
    ZHANG J, LIU S S, DOU R N, et al. Evaluation on the toxicity of ionic liquid mixture with antagonism and synergism to Vibrio qinghaiensis sp.-Q67[J]. Chemosphere, 2011, 82(7):1024-1029.
    [25]
    窦容妮, 刘树深, 刘海玲,等. 部分含 J-型剂量-效应关系二元混合物的毒性效应[J]. 生态毒理学报, 2010, 5(4):498-504.
    [26]
    BREZOVŠEK P, ELERŠEK T, FILIPIČ M. Toxicities of four anti-neoplastic drugs and their binary mixtures tested on the green alga Pseudokirchneriella subcapitata and the cyanobacterium Synechococcus leopoliensis[J]. Water Research, 2014, 52:168-177.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (57) PDF downloads(4) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return